人参总皂苷对小鼠的抗抑郁作用  

Antidepression Action of Total Ginsenoside Extracts in Mice

作　　者：陶震 鲁毅[1] 司梁宏[1] 陆瑜[1] 邱彦[1] 

机构地区：[1]解放军第四五四医院药剂科,南京210002

出　　处：《药学与临床研究》2010年第4期360-362,共3页Pharmaceutical and Clinical Research

摘　　要：目的:初步探讨人参总皂苷对小鼠的抗抑郁作用。方法:选取健康雄性昆明种小鼠,随机分为5组,空白对照组、阳性药组、人参总皂苷125、250、500 mg.kg-1剂量组。通过小鼠自主活动实验、小鼠强迫游泳实验和小鼠悬尾实验,观察人参总皂苷对小鼠抗抑郁作用的影响。结果:各给药组小鼠自主活动行为与空白对照组比较均无明显差异;人参总皂苷125、250、500 mg.kg-1均可以显著缩短小鼠强迫游泳及小鼠悬尾不动时间。结论:实验结果表明人参总皂苷在小鼠"行为绝望"模型中有一定的抗抑郁作用。Objective：To investigate the antidepressant effects of Ginsenoside extracts in depression mice.Methods：Select the healthy male KM mice and randomly divided into 5 groups：a blank control group,positive control and Ginsenoside extracts of 125,250,500 mg.kg^-1 groups.By using mouse tail suspension test,mouse forced swimming test and autonomic activity test,the antidepressant effects of Ginsenoside extracts were observed.Results：Comparing with the blank control group,none of the extracts at the testing doses had marked effect on autonomic activity in mice.The Ginsenoside extracts 125,250,500 mg.kg^-1 could significantly decrease the time of immobility in the tail suspension test and the time of forced swimming.Conclusion：These results show that Ginsenoside extracts had the obvious antidepressant effect on depressive mouse model.

关 键 词：人参总皂苷 抗抑郁 悬尾实验 强迫游泳实验 

分 类 号：R965.1[医药卫生—药理学]