重症监护室内右旋美托咪啶引发的手术后药物热  

作　　者：Tadashi Okabe Shinhiro Takeda Shinji Akada Takashi Hongo Atsuhiro Sakamoto 王斐(译) 王焱林(校) 

机构地区：[1]Department of Anesthesiology and Intensive Care Medicine, Nippon Medical School, Tokyo, Japan [2]不详

出　　处：《麻醉与镇痛》2010年第4期81-83,共3页Anesthesia & Analgesia

摘　　要：盐酸右旋美托咪啶是一种有效的、高选择性的α-2受体激动剂，它作为一种镇静药在重症监护室（ICU）得到广泛的应用。本文我们报道一例由盐酸右旋美托咪啶引发的药物热。患者年龄59岁，因腹主动脉瘤破裂收入ICU。患者在开始应用盐酸右旋美托咪啶镇静后出现发热，体温超过39℃。停药7小时后，发热症状迅速缓解。其间排除其他可能引起发热的原因（如感染）。Dexmedetomidine hydrochloride is a potent, highly selective α-2 adrenergic receptor agonist, broadly used as a sedative drug in intensive care units. We describe the case of a 59-yr-old patient who experienced drug fever caused by dexmedetomidine hydrochloride. The patient was transferred to the intensive care unit with an abdominal aortic aneurysm rupture. After initiation of sedation with dexmedetomidine hydrochloride, he developed pyrexia of more than 39℃. This symptom improved rapidly 7 h after stopping dexmedetomidine hydrochloride. Other possible causes （such as infection） were sequentially eliminated.

关 键 词：右旋美托咪啶 重症监护室 药物热 引发 手术后 腹主动脉瘤破裂 室内 2受体激动剂 

分 类 号：R971.93[医药卫生—药品]