青藤碱贴剂的药动学研究  

The Pharmacokinetics Study on Sinomenine Transdermal Patch on Anaesthetized Beagle Dogs

作　　者：张英丰[1] 于洋[1] 周莉玲[1] 

机构地区：[1]广州中医药大学,广东广州510006

出　　处：《中药材》2010年第6期944-947,共4页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金资助项目(30672669);中国博士后基金资助项目(20070420509)

摘　　要：目的:研究青藤碱贴剂的药动学。方法:以Beagle犬为研究对象,以HPLC-UV为检测手段,测定给药以后不同时间点的血药浓度,拟合药动学参数。结果:建立了专属性的青藤碱血药浓度检测方法,青藤碱贴剂血药浓度达峰时间约8 h,MRT约13 h,达峰浓度约366 ng/mL,其体内行为属于一级速率、二室开放模型。结论:本方法灵敏、快速、选择性强,较好的满足青藤碱的药动学研究。Objective：To explore the pharmacokinetic of Sinomenine transdermal patch.Methods：The plasma drug concentration of Beagle dogs was determined after administration with HPLC-UVD as analysis tools.The pharmacokinetics parameters were fitted with kinetica software package.Results：The exclusive analysis method was established with the following pharmacokinetics parameters：T（peak）= 8 h,Cmax= 366 ng/mL,MRT=13 h.The pharmacokinetic characteristics was accordance with one-order rate and two-compartment model.Conclusion：The method is perferable to be applied to the pharmacokinetics research and further applied pharmacological study which will play a reference role in clinical application.

关 键 词：青藤碱贴剂 BEAGLE犬 药动学 

分 类 号：R285.5[医药卫生—中药学]