老年2型糖尿病患者血25羟维生素D3水平与早相胰岛素分泌的关系  

Relationship between the serum level of 25-hydroxyvitamin D_3 and early-phase insulin secretion in elderly patients with type 2 diabetes

作　　者：阙凤连[1] 黄国良[2] 

机构地区：[1]福建医科大学协和临床学院,福州市第七医院内科,350001 [2]福建医科大学附属协和医院 福建省内分泌研究所

出　　处：《中国糖尿病杂志》2010年第8期614-616,共3页Chinese Journal of Diabetes

摘　　要：目的探讨老年2型糖尿病(T2DM)患者血25羟维生素D_3(VD_3)水平与早相胰岛素分泌的关系。方法选择老年DM前期40例为A组、新诊断T2DM 40例为B组、经治T2DM 50例为C组、老年健康者50名为对照(NC)组。ELISA法测定血VD_3,以△I_(30)/△G_(30)及HOMA-β反映早相胰岛素分泌功能。结果从NC到A、B及C组,随糖代谢紊乱的逐渐加重,VD_3水平逐渐降低(P均<0.05)。130例糖代谢异常患者随VD_3水平逐渐增高,早相胰岛素分泌功能逐渐好转(P均<0.05);反之,随早相胰岛素分泌功能逐渐好转,VD_3水平逐渐增高(P均<0.05)。回归分析显示,VD_3与早相胰岛素分泌功能呈正相关(P均<0.05)。结论老年T2DM患者存在VD_3缺乏,可能是导致其早相胰岛素分泌功能障碍的因素之一。Objective To study the relationship between the level of VD3 and early-phase insulin secretion in elderly patients with T2DM. Methods The 40 newly diagnosed T2DM subjects, 50 treated T2DM subjects,40 IGT/IFG subjects and 40 healthy subjects were divided into A,B,C and control group respectively. The serum level of VD3 was determined by ELISA. And OGTT, △I30/△G30 ratio and HOMA-β were done and calculated. Results The levels of VD3 △I30/△G30 and HOMA-β were higher in study groups than in control group （all P〈 0. 05）. The regression correlation analysis showed the positive correlation of VD3 level with △I30/△G30 ratio and HOMA-13（r = 0.40, r= 0.29 respectively, all P 〈0.05）. Conclusions The elderly patients with T2DM have lower VD3 levels, which may be one of factors resulting in the impaired early phase insulin secretion.

关 键 词：25羟维生素D3 糖尿病 2型 早相胰岛素分泌 

分 类 号：R587.1[医药卫生—内分泌]