人工周期方案下冻融胚胎移植的安全性评价  

Safety evaluation of frozen-thawed embryo transfer in artificial cycles

作　　者：刘风华[1] 何玲[1] 李旎[1] 龙晓林[1] 张伟良[1] 杜红姿[1] 黄青[1] 刘见桥[1] 许海燕[1] 

机构地区：[1]广州医学院第三附属医院生殖助孕科,510150

出　　处：《中华生物医学工程杂志》2010年第2期151-154,共4页Chinese Journal of Biomedical Engineering

摘　　要：目的 评价人工周期方案下行冻融胚胎移植（FET）的安全性.方法 2004年1月至2008年6月本院进行的1397个FET周期分2组：即人工周期组[人工周期方案（戊酸雌二醇片＋黄体酮针）,420个周期]和自然周期组（对照组,自然周期方案,977周期）.比较两组间临床妊娠率、种植率、分娩率、流产率、异位妊娠率、多胎妊娠率、单胎低出生体质量率、单胎早产率及出生缺陷率等指标,评价人工周期方案下FET的安全性.结果 人工周期组和自然周期组的临床妊娠率[26.2%（110/420）和23.9%（233/977）]、种植率[13.7%（142/1034）和12.6%（299/2369）]、分娩率[69.1%（76/110）和76.0%（177/233）]、流产率[22.7%（25/1 10）和18.0%（42/233）]、异位妊娠率[2.7%（3/110）和3.0%（7/233）]、多胎妊娠率[26.4%（29/110）和24.9%（58/233）]、单胎低出生体质量率[1.6%（1/63）和4.4%（6/138）]、单胎早产率[9.5%（6/63）和7.3%（10/138）]、出生缺陷率[0%（0/420）和0%（0/977）]、男胎分娩率[53.8%（43/80）和54.2%（96/177）]及女胎分娩率[46.2%（37/80）和45.8%（81/177）]差异均无统计学意义（P〉0.05）.结论 近期评价人工周期方案下行FET是安全的.Objective To evaluate the safety of frozen-thawed embryo transfer （FET） in artificial cycles. Methods A retrospective study was conducted on 1397 cycles of FET which comprised two groups：an artificial cycle group using the artificial cycle treatment （Estradiol Valerate tablets plus Progesterone injection,420 cycles） and a natural cycle group using the natural cycle treatment （the control group,977 cycles）. All the cycles were completed in our hospital between January 2004 and June 2008. The rates of clinical pregnancy,implantation,delivery,abortion,ectopic pregnancy,multiple pregnancy,low-birth-weighted singletons,premature-delivered singletons and birth defects were compared between two groups,so as to evaluate the safety of frozen-thawed embryo transfer （FET） in artificial cycles. Results There were no significant differences between the artificial and natural cycle groups with regard to the rates of clinical pregnancy[26.2 % （110/420） vs 23.9% （233/977）],implantation[13.7% （142/1034） vs 12.6% （299/2369）],delivery[69.1% （76/110） vs 76.0% （177/233）],abortion[22.7% （25/110） vs 18.0% （42/233）],ectopic pregnancy[2.7% （3/110）.vs 3.0 % （7/233）]multiple pregnancy[26.4% （29/110） vs 24.9% （58/233）],low-birth-weighted singletons[1.6% （1/63） vs 4.4% （6/138）],prematurely delivered singletons[9.5% （6/63） vs 7.3% （10/138）],birth defects[0% （0/420） vs 0% （0/977）],delivery of male neonates[53. 8% （43/80） vs 54. 2% （96/177）]and delivery of female neonates[46.2% （37/80） vs 45.8% （81/177）]（all P〉0.05）. Conclusion FET in artificial cycles can be safe in the near future evaluation.

关 键 词：胚胎移植 妊娠率 种植率 人工周期 自然周期 

分 类 号：R714.8[医药卫生—妇产科学]