自体骨髓干细胞移植配合中药治疗糖尿病足溃疡的疗效及其与血清VEGF水平关系的研究  

Curative Effect of Combination of Autologous Bone Marrow Stem Cell Transplantation with Traditional Chinese Medicine on Diabetic Foot and Its Relation with Serum Level of Vascular Endothelial Growth Factor

作　　者：甘宇[1] 李铁男[1] 于黎丽[1] 郑长虹[1] 金荣杰[1] 裴洪利[1] 贾鹏[1] 郭贞臻[1] 张继斌[1] 陈盛业[1] 谌静[1] 王丽[1] 

机构地区：[1]沈阳市第七人民医院,沈阳110003

出　　处：《中国中西医结合皮肤性病学杂志》2010年第4期206-209,共4页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：沈阳市科技基金资助项目(1071194-9-00)

摘　　要：目的探讨自体骨髓干细胞移植与中药合用治疗糖尿病足的疗效及其与血清血管内皮生长因子(VEGF)水平的关系。方法选择80例因慢性下肢缺血引起糖尿病足溃疡患者,分为常规治疗组(A组),中药治疗组(B组),自体骨髓干细胞移植治疗组(C组),自体骨髓干细胞移植与中药合用治疗组(D组),每组各20例,各40条患肢。治疗3个月,观察各项指标,对疗效及其与血清VEGF水平关系进行评估。结果①治疗后1周,C、D两组肢体疼痛、患肢冷感、皮肤温度、血清VEGF水平与治疗前比较差异有统计学意义(P<0.05);血清VEGF水平与肢体疼痛、患肢冷感、皮肤温度之间存在相关性(P<0.05)。治疗后1个月、3个月血清VEGF水平与治疗前比较差异无统计学意义(P>0.05)。②治疗后1周C、D两组肢体疼痛、患肢冷感、皮肤温度、血清VEGF水平与A、B组比较差异有统计学意义(P<0.05)。③治疗后3个月,C、D两组各项临床观察指标与治疗前比较差异均有统计学意义(P<0.05);D组除踝臂指数外其他各项临床观察指标与C组比较差异均有统计学意义(P<0.05)。④自体骨髓干细胞移植与中药合用可以提高糖尿病足的疗效,存在交互作用(P<0.05)。结论自体骨髓干细胞移植技术与伍用中药治疗慢性下肢缺血引起糖尿病足溃疡可以提高疗效,不会导致由于血清VEGF水平长期增高引起的副作用。Objective To probe curative effect of combination of autologous bone marrow stem cell transplantation with traditional Chinese medicine on diabetic foot and its association with serum level of vascular endothelial growth factor（VEGF）. Methods According to the design of two-way ANOVA, 80 diabetic foot cases caused by chronic lower limb ischemia were divided into regular treatment group （group A）; traditional Chinese medicine treatment group （group B）; autologous bone marrow stem cell transplantation treatment group （ group C）; and group treated by combination of autologous bone marrow stem cell transplantation with traditional Chinese medicine （group D）. Each group included 20 cases, 40 affected limbs. The parameters were observed. And the curative effect as well as serum level of VEFG was evaluated after three-month treatment. Results （1） After one-week treatment, there was statistical significance in limb pain, cold feeling of affected limbs, skin temperature, serum level of VEGF among group C, D compared with pretreatment （P 0.05）. There was a correlation between serum level of VEGF and limb pain, cold feeling of affected limbs and skin temperature（P0.05）. There was no significant difference in the serum level of VEGF comparing one-month, three-month treatment with pretreatment （P0.05）. （2） There was statistical significance in serum level of VEGF, limb pain, cold feeling of affected limbs and skin temperature between group C, D and group A, B （P0.05）. （3） After three-month treatment, clinical parameters showed statistical significance compared with pretreatment between group C and D （P0.05）. Except the ankle-brachial index, there was statistical significance in other clinical parameters between group D and group C （P 0.05）. （4） The curative effect was improved by combing autologous bone marrow stem cell transplantation with traditional Chinese medicine. There was interaction （P 0.05）. Conclusion The curative effect of diabetic foot caused by chron

关 键 词：骨髓干细胞移植 自体 中药 糖尿病足 血管内皮生长因子 

分 类 号：R587.1[医药卫生—内分泌] R753.7[医药卫生—内科学]