荆芥连翘汤湿敷对急性放射性皮肤溃疡愈合的影响  

Effect of wet dressing with Jingjielianqiao decoction on healing of acute radiation-induced skin ulcers in rats

作　　者：兰海梅[1] 种树彬[1] 赖梅生[2] 曾抗[1] 

机构地区：[1]南方医科大学南方医院皮肤科,广东广州510515 [2]南方医科大学中医药学院,广东广州510515

出　　处：《南方医科大学学报》2010年第7期1600-1603,共4页Journal of Southern Medical University

基　　金：广东省自然科学基金(7300345)

摘　　要：目的观察荆芥连翘汤湿敷对急性放射性皮肤溃疡的治疗作用。方法建立大鼠急性放射性皮肤溃疡模型,比较荆芥连翘汤、利凡诺及生理盐水三组的小腿肿胀度,观察三组的皮损改善情况。结果在抗炎方面,荆芥连翘汤组和利凡诺组没有显著性差异(P>0.05),但两组与生理盐水组相比均有显著性差异(P<0.01);在溃疡愈合方面,三组的疗效差异有显著性意义(P<0.01);结论荆芥连翘汤湿敷对放射线引起的急性炎症具有明显的抑制作用,能促进急性放射性皮肤溃疡的愈合,其促进溃疡愈合的疗效优于利凡诺。Objective To observe the pharmacodynamics of Jingjielianqiao decoction in promoting the healing of acute radiation-induced skin ulcers in mice. Methods Skin ulcers were induced in mice by radiation, and Jingjielianqiao decoction, rivanol or normal saline was applied for the treatment. The swelling of the legs was measured in mice using volumetric method, and the ulcer area after treatment was compared among the 3 groups. Results No significant difference was found in the anti-inflammatory effects between Jingjielianqiao decoction group and rivanol group （P0.05）, but a significant difference was noted between Jingjielianqiao decoction group and normal saline group and also between rivanol group and normal saline group （P0.01）. Significant differences were observed in the ulcer healing among the 3 groups （P0.01）. Conclusion Jingjielianqiao decoction can significantly suppress radiation-induced acute inflammation and shows better effect than rivanol in promoting the healing of acute radiation-induced skin ulcer in rats.

关 键 词：荆芥连翘汤 急性放射性皮肤溃疡 湿敷疗法 

分 类 号：R285.5[医药卫生—中药学]