珠海地区653名成年女性骨密度及CTx测量分析  

Investigation of bone mineral density and serum type I collagen C-telopeptide in 653 female adults in Zhuhai area

作　　者：王建钧[1] 张晓荣[1] 李晓冬[1] 

机构地区：[1]暨南大学第三附属医院/珠海市人民医院脊柱骨病科,广东珠海519000

出　　处：《南方医科大学学报》2010年第7期1612-1614,共3页Journal of Southern Medical University

基　　金：珠海市卫生局科研基金

摘　　要：目的检测并分析珠海地区653例成年女性腰3椎体和股骨颈Ward's三角区骨密度及血清CTx值(I型胶原C末端肽),为骨质疏松的诊断和预防提供科学依据。方法根据纳入标准选择653例成年女性,分别检测L3椎体和左股骨颈的Ward's三角区BMD,测定血清CTx值并进行统计学分析。结果珠海地区成年女性腰3椎体峰值骨密度出现在30～39岁组,股骨颈Ward's三角区出现在20～29岁组,各年龄段骨密度均有明显差异(P<0.01);股骨颈Ward's三角区骨密度较腰3椎体下降早一个年龄段;血生化中血清CTx随着年龄的变化逐渐升高,除20～29岁组和30～39岁组间,30～39岁组和40～49岁组间,其余各组间都存在明显的统计学差异(P<0.01);骨质疏松症的患病率随年龄增长而增加,腰3椎体的患病率在50～59岁和60～69岁年龄段急剧上升并随年龄增加维持在高水平,股骨颈Ward's三角的患病率在达到峰值骨密度年龄段后即出现明显的上升趋势,同年龄段股骨颈Ward's三角区骨质疏松症的患病率明显高于腰3椎体。结论成年女性腰3椎体骨密度和血清CTx值随年龄变化较大,尤以更年期影响明显,股骨颈Ward's三角区骨密度降低与女性更年期无明显关系。Objective To study the bone mineral density （BMD） of the third lumbar vertebrae and the Ward＇s triangle in the femoral neck and serum type I collagen C-telopeptide （CTx） level in female adults and provide scientific evidence for diagnosis and prevention of osteoporosis. Methods According to the inclusion criteria, 653 female adults were examined for BMD of the third lumbar vertebrae and the Ward＇s triangle in the femoral neck and the level of serum CTx. Results The peak of BMD in the third lumbar vertebrae occurred in 30-39 years of age, and that of the Ward＇s triangle in the femoral neck occurred in 20-29 years of age, showing significant differences between the age groups （P0.01）. The BMD of the Ward＇s triangle in the femoral neck decreased earlier than that of the third lumbar vertebrae by one age period. The level of serum CTx increased with age, showing significant differences between the age groups （P0.01） but not between the 20-29 years and the 30-39 groups, or between 30-39 and the 40-49 years groups. The prevalence of osteoporosis increased also with age, and osteoporosis in the third lumbar vertebrae increased rapidly in the 50-59 years and the 60-69 years groups, maintaining a high level in older ages. The prevalence of osteoporosis in the Ward＇s triangle in the femoral neck increased obviously after the peak of BMD, maintaining a significantly higher level than that of the third lumbar vertebrae in the same age group. Conclusions The BMD in the third lumbar vertebrae and the level of serum CTx undergo obvious changes with age, especial in menopause. There is no obvious relation between decreased BMD in the Ward＇s triangle in the femoral neck and menopause.

关 键 词：成年女性 骨质疏松症 骨密度 I型胶原C末端肽 

分 类 号：R816.8[医药卫生—放射医学]