IL-1β-511和IL-1RN VNTR基因多态性与冠心病相关性的Meta分析  

Correlation of IL-1β-511 and IL-1RN VNTR gene polymorphism to coronary heart disease: a Meta-analysis

作　　者：陈凡[1] 程文[2] 

机构地区：[1]中南大学湘雅医院心血管内科,湖南长沙410008 [2]中南大学基础医学院免疫学系,湖南长沙410078

出　　处：《南方医科大学学报》2010年第7期1635-1638,共4页Journal of Southern Medical University

摘　　要：目的 Meta分析评价IL-1β-511和IL-1RNVNTR基因多态性与冠状动脉粥样硬化性心脏病相关性。方法设定入选条件,文献检索收集关于IL-1β-511和IL-1RNVNTR基因多态性与冠心病关系的病例-对照研究,对相关研究进行同质性检验并合并数据进行Meta分析。结果 7个有关IL-1β-511多态性与冠心病相关研究合并OR值为1.04,95%CI为0.93～1.18(Z=0.71,P=0.48);5个IL-1RNVNTR基因多态性与冠心病相关研究合并OR值为1.01,95%CI为0.78～1.17(Z=0.08,P=0.93)。结论 IL-1β-511和IL-1RNVNTR基因多态性与冠心病易感性无明显相关,但可能影响冠心病的发展和临床表现的变化。Objective To evaluate the correlation between the gene polymorphism of IL-1β-511 or IL-1RN VNTR and the risk of coronary heart disease （CHD）. Methods The patient-control studies on the association of IL-1β-511 or IL-1RN VNTR gene polymorphism with the risk of CHD were searched according to the inclusion criteria. Heterogeneity tests were conducted for the data from each study before Meta-analysis. Results For the 7 studies addressing the correlation between IL-1β-511 polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.04 with 95% CI of 0.93-1.18 （Z=0.71, P=0.48）. For the 5 studies of the correlation between IL-1RN VNTR polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.01 and the 95% CI was 0.78-1.17 （Z=0.08, P=0.93）. Conclusion The gene polymorphism of IL-1β-511 or IL-1RN VNTR has no correlation to the susceptibility of CHD, but is associated with in the disease development and clinical phenotype.

关 键 词：冠状动脉粥样硬化性心脏病 IL-1基因多态性 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]