血清ANGPTL3含量与老年代谢综合征的关系  

The serum ANGPTL3 levels in elderly patients with metabolic syndrome

作　　者：王继红[1] 肖亚雄 孔渝菡[1,2] 王永红[1,3] 李晞 任晓玲[1] 陈瑶 

机构地区：[1]重庆医科大学基础医学实验教学中心生物化学与分子生物学实验室,重庆医科大学分子医学与肿瘤研究中心,重庆400016 [2]重庆医科大学附属第一医院神经病学实验室 [3]重庆医科大学附属第一医院体检中心

出　　处：《中国老年学杂志》2010年第16期2248-2250,共3页Chinese Journal of Gerontology

基　　金：重庆市科委自然科学基金(CSTC,2008CE9142);重庆医科大学创新基金(No.CX200528)

摘　　要：目的通过测定人血清血管生成素样蛋白3(angiopioetin-like protein3,ANGPTL3)的表达水平,探讨ANGPTL3表达量与代谢综合征(Metabolic syndrome,MS)的关系。方法随机筛选12例老年MS患者为MS组,以10例健康受试者为对照组,采用酶联免疫吸附法(ELISA)检测每例受试者血清ANGPTL3蛋白质水平。结果 MS组ANGPTL3平均值为(69.15±41.63)mg/L,对照组为(30.81±9.12)mg/L,组间比较差异有统计学意义(P<0.05)。MS组内女性血清ANGPTL3蛋白质浓度明显高于男性,差异有统计学意义(P<0.05),而对照组内男、女两性血清ANGPTL3蛋白质浓度差异无统计学意义。结论老年MS病人体内ANGPTL3含量明显升高,ANGPTL3可能在老年MS病人体内脂代谢和糖代谢紊乱过程中发挥了重要作用。Objective To discuss the relationship between the level of serum angiopoietin-like protein 3（ANGPTL3）and metabolic syndrome（MS） patients.Methods 12 elderly MS patients were randomly selected.The enzyme-linked immunosorbent assay （ELISA） was used to detect the the level of ANGPTL3 in MS patients’ serum.10 healthy person were taken as control group.Results The level of ANGPTL3 in MS patients was significantly higher than that in control group 〔（69.15±41.63） vs （30.81±9.12） mg/L,P0.05〕.In MS group,the level of ANGPTL3 in women was significantly higher than that in men（P0.05）,but the statistical significance was not found in the control group.Conclusions ANGPTL3 level in elderly MS patients is significantly higher than that in control group,ANGPTL3 may play an important role in the process of lipometabolic disturbance and glycometabolic disorder in MS.

关 键 词：血管生成素样蛋白3 代谢综合征 脂代谢紊乱 糖代谢紊乱 

分 类 号：R33[医药卫生—人体生理学]