沈阳地区2004年-2009年志贺菌菌型分布及耐药性分析  

Change in strain types and drug-susceptibility of Shigella from 2004 to 2009 in Shenyang

作　　者：李继耀[1] 高丹[1] 董雪[1] 

机构地区：[1]辽宁省沈阳市疾病预防控制中心,沈阳110031

出　　处：《中国卫生检验杂志》2010年第8期1999-2000,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:了解沈阳地区2004年-2009年细菌性痢疾的病原菌志贺菌菌型分布及其药物敏感状况,为细菌性痢疾临床治疗和预防控制提供依据。方法:按《全国细菌性痢疾监测方案》的要求进行检测。结果:2004年-2009年期间检测出志贺菌总计87株,志贺菌共分2个群,B群46株(52.87%),D群41株(47.13%)。福氏志贺菌主要以福氏1a和福氏2a为主,各15株,占福氏志贺菌的65.22%。药敏结果显示,敏感药物为环丙沙星(95.40%),其次为头孢噻吩(80.46%)、头孢噻肟(87.26%)、庆大霉素(69.00%)。耐药的有氨苄西林(90.80%)、奈啶酸(94.55%)、四环素(96.55%)、利福平(94.55%)和复方新诺明(89.65%)。结论:2004年-2009年沈阳地区细菌性痢疾病原菌主要是福氏志贺菌和宋内氏志贺菌,并且宋内氏志贺菌感染呈上升趋势,志贺菌对目前常用的抗生素表现一定的耐药性。Objective：To have a better understanding of the predominant strains of Shigella causing dysentery and their sensitivity to different drugs in Shenyang.So as to provide suggestion for shigellosis prevention and rational prescriptions.Methods： Detection according to the〈Nation Project for Surveillance on Bacterial Dysentery was〉 made.Results：During the 2004-2009 detect Shigellae infection,87 strains of Shigella infection was divided two groups,group B46 strains（52.87%）,group D 41 strains（47.13%）.Sh.Flexneri 1a and 2a were 65.22%.Drug sensitivity tests realed that Shigella were sensitive to ciprofloxacin（95.40%）,cefotaxime（87.26%）,gentamicin（69.00%） and l were resistant to ampicillin（90.80%）,nalidixic acid（94.55%）,tetracycline（96.55%）,rifampicin（94.55%）,compound Liguorice（89.65%）.Conclusion： The prevailing pathogenic bacteria of bacterial dysentery were Sh.Flexneri and Sh.Sonne in Shenyang from 2004 to 2009,Sh.Sonne were ascendant trend,all of them showed resistant to commonly used antibiotics.

关 键 词：志贺菌 菌型 药物敏感性 

分 类 号：R446.5[医药卫生—诊断学]