肠抑素与高脂血症大鼠肾损害关系的研究  

Enterostatin and rats with renal injury induced by hyperlipidemia

作　　者：肖云[1] 谢辉[1] 肖洁[1] 张萌[2] 吴峻[2] 

机构地区：[1]广州医学院第一附属医院肾内科,广东广州510120 [2]广州医学院第一附属医院心血管内科,广东广州510120

出　　处：《中国现代医学杂志》2010年第14期2139-2141,2145,共4页China Journal of Modern Medicine

基　　金：广州市医药卫生科技项目资助(No:2007-YB-149)

摘　　要：目的探讨肠抑素与高脂血症大鼠肾损害的关系以及辛伐他汀对高脂血症肾损害的可能保护机制。方法实验分为3组,正常对照组、高脂血症模型组和辛伐他汀(10mg/kg·d))治疗组,12周后检测3组大鼠的血脂、血肌酐、24h尿蛋白水平,以及血清和肾皮质肠抑素浓度。结果高脂血症组大鼠尿蛋白明显高于正常对照组(P<0.01),血清和肾皮质肠抑素水平低于正常对照组(P<0.05)。辛伐他汀治疗组总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)、24小时尿蛋白定量显著低于高脂血症组(P<0.01),血清和肾皮质肠抑素含量高于高脂血症组(P<0.05)。结论辛伐他汀在调脂的同时,还能显著增加血清肠抑素水平,肠抑素水平的降低可能参与了高脂血症肾损害的发生、发展。[Objective] To investigate the relation of enterostatin and lipid-renal damage rats and the mechanism of Simvastati in protecting it. [Methods] Thirty rats were randomly divided into 3 groups： control group, hyperlipidemic group （HL-untreated） and Simvastati -treated group （IlL-treated, 10 mg/d/kg）, the serum levels of lipid, Cr, urine protein and enterostatin content in serum and renal cortex were measured. [Results] Hyperlipidemic rats had higher level of urine protein （P〈0.01） and lower level of enterostatin in serum and renal cortex compared with those of control subjects （P 〈0.05）. Significant decrease of level of urine protein and serum lipid and increase of enterostatin in serum and renal cortex were found in Simvastati-treated rats （P〈0.05）. [Conclusion] Simvastati can regulate dyslipidemia, increase the enterostatin content in serum and decrease urine protein. Decrease of enterostatin may be one of the most mechanism of lipid-renal damage.

关 键 词：辛伐他汀 高脂血症 肾 肠抑素 

分 类 号：R692.6[医药卫生—泌尿科学]