脑电双频指数监测下丙泊酚靶控镇静在眼科手术中的应用  

Application of TCI propofol sedation under BIS monitoring in ophthalmic surgery

作　　者：范雪梅[1] 徐源[1] 李梅[1] 李天佐[1] 

机构地区：[1]首都医科大学附属北京同仁医院麻醉,100730

出　　处：《临床麻醉学杂志》2010年第6期491-493,共3页Journal of Clinical Anesthesiology

摘　　要：目的观察丙泊酚靶控输注(TCI)在眼科手术中的镇静效果。方法成人局麻下眼底手术患者60例,随机均分为Ⅰ、Ⅱ、Ⅲ组,分别TCI丙泊酚0.5、1.0和1.5μg/ml。分别于入室后5 min、球后阻滞、手术开始30 min、眼底激光及手术结束时记录HR、MAP、SpO2、BIS值和Ramsay镇静评分。结果Ⅲ组术中各时点的Ramsay评分高于Ⅰ组(P<0.05),但术中4例出现呼吸抑制,2例发生体动反应,而Ⅰ、Ⅱ组未见上述不良反应。结论在局麻眼底手术中,采用丙泊酚1.0μg/ml TCI镇静较为适宜。Objective To observe the efficacy of sedation by TCI propofol.Methods Sixty patients undergoing selective ophthalmic surgery with local anesthesia were randomized into three groups of I,Ⅱ and Ⅲ,who were sedated with propofol by TCI propofol 0.5,1.0 or 1.5 μg/ml,respectively.Retrobulbar block was taken after plasma-effect site equilibration.BIS,HR,MAP,SpO2 and Ramsay score were recorded at 5 min after entering operating room,during retrobulbar anesthesia,at 30 min after incision,at the time of eyeground laser and the end of operation.Results Ramsay score was higher in group Ⅲ than that in group I（P〈0.05）.Respiratory depression was seen in 4 cases and body motion occurred in 2 cases in group Ⅲ.Conclusion Propofol 1.0 μg/ml given by TCI can produce optimal depth of sedation with less side effects in eyeground surgery with local anesthesia.

关 键 词：镇静 丙泊酚 靶控输注 脑电双频指数 

分 类 号：R614[医药卫生—麻醉学]