双黄连注射剂降压作用初探  

Study on Depressor Effect of Shuanghuanglian Injection

作　　者：牛慧玲[1] 马辉[1] 肖佳音[1] 李庆忠[1] 张雅芬 周盛琦 

机构地区：[1]黑龙江省药品检验所,哈尔滨150001 [2]哈尔滨市眼科医院,哈尔滨150001 [3]黑龙江省药品不良反应检测中心,哈尔滨150076

出　　处：《中国药品标准》2010年第4期256-259,共4页Drug Standards of China

摘　　要：目的:观察双黄连注射剂静脉给药对猫的急性降压作用,为该注射剂设立降压物质检查提供依据。方法:参照《中国药典》2005年版二部附录"降压物质检查法",对不同企业生产的不同双黄连注射剂剂型按不同剂量静脉给药,观察并记录降压作用。结果:双黄连注射液1 mL.kg-1(与临床人用量相当)、双黄连静脉输液1 mL.kg-1(1/10临床人用量)、注射用双黄连(冻干和粉针)12 mg.kg-1(1/5临床人用量)对麻醉猫静脉注射给药,结果表明双黄连注射剂均有不同程度的降压作用。同时表明注射速度和浓度直接影响双黄连注射剂的降压作用强度。Objective： To observe the acute depressor effect of Shuanghuanglian Injection in cat,and to provide reference for establishing a method to determine depressor substance in Shuanghuanglian Injection. Methods： According to the appendix XIG of Chinese Pharmacopocia 2005 vol Ⅱ ,the blood pressure response of the cat caused by injecting different dose form of Shuanghuanglian Injection produced by different manufactures was observed and recorded. Result： The experiment suggested Shuanghuanglian Injection had different depressor effect when cats were given drug at the dose of 1 mL · kg^-1 （Shuanghuanglian Injection and Shuanghuanglian Injection for transfusion）, being one fives of clinical dose and one tens of clinical dose;at the dose of 12 mg· kg^-1（ Shuanghuanglian Powder）, being one fives of clinical dose. It also showed the depressor effect of Shuanghuanglian Injection was affected by injection speed and concentration.

关 键 词：不良反应 降压作用 注射速度 注射浓度 

分 类 号：R285.1[医药卫生—中药学]