缺血性脑血管疾病与代谢综合征及颈动脉粥样硬化的关系  

Correlation of ischemic cerebrovascular diseases with metaboli syndrome and carotid artery atherosclerosis

作　　者：周平[1] 谢满红[1] 王东刚[1] 钱江南[1] 周华民[1] 

机构地区：[1]航空医学研究所附属医院神经内科,北京100089

出　　处：《中国急救复苏与灾害医学杂志》2010年第8期707-709,715,共4页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的探讨颈动脉粥样硬化及代谢综合征与缺血性脑血管疾病发生的关系。方法357例缺血性脑血管病患者（短暂脑缺血发作109例，脑梗死248例），接受颈动脉血管超声、体重、腹围、血脂、血糖、血压、吸烟状况、心脏情况等检查。以非条件Logistic回归分析动脉粥样硬化、代谢综合征、高血压、糖尿病、高脂血症等因素间的相关性。结果①89．1％（318／357）患者存在颈动脉粥样硬化。26．9％（96／357）患者存在颈动脉中重度狭窄，其中短暂脑缺血组颈动脉中重度狭窄的比例为43．1％（47／109），高于脑梗死组（19．8％，49／248，P〈0．01）。②糖尿病、高血压、高血脂、代谢综合征与颈动脉粥样硬化有明显相关性（均P〈0．01），代谢综合征患者颈部动脉狭窄率达41．9％，显著高于糖尿病、高血压、高血脂组（分别为26．4％，28．9％，及24．4％，均P〈0．01）。结论颈动脉粥样硬化与缺血性脑血管疾病的发生显著相关，代谢综合征与颈动脉血管狭窄显著相关。控制高血压、糖尿病、高血脂及代谢综合征对预防缺血性脑血管疾病的发生意义重大。Objective To analyse the relationship of ischemic cerebrovascular disease between metabolic syndrome and carotid artery atherosclerosis. Methods 357 patients of ischemic cerebrovascular disease, 109 with transient ischemic attack （TIA） and 248 with cerebral infarction underwent color Doppler ultrasonography of carotid artery system , measurement of body weight, abdominal circumference, and blood pressure, testing of blood lipids and blood glucose, and investigatin of smoking status and cardiac disease. Logistic regression was used to analyze the relationships among these factors. Results @89.1% （318/357）of the 357 patients had carotid artery atherosclerosis, and 96 patients （26.9%） were at middle to serious degrees. The rate of middle to serious degree carotid artery atherosclerosis of the transient ischemic attack （TIA） group was 41.9%, 47/109）, significantly higher than that of the cerebral infarction group （ 19.8%, 49/248, P〈0.01 ）.@Carotid artery atherosclerosis （CAS） was positively correlated with hypertension, diabetes, hyperlipemia, and metabolic syndrome （all P〈0.01） The carotid artery stenosis rate of the patients with metabolic syndrome was 41.9%, significantly higher than those of the patients with diabetes, hypertension, and hyperlipemia （26.4% , 28.9% ,and 24.4% respectively, all P〈0.01 ）. Conclusion Carotid artery atherosclerosis is significantly correlated with carotid artery diseases. Control of hypertension, diabetes, hyperlipemia, and metabolic syndrome is significant in prevention of ischemic cerebrovascular diseases.

关 键 词：缺血性脑血管疾病 颈动脉粥样硬化 代谢综合征 危险因素 

分 类 号：R543[医药卫生—心血管疾病]