高温高强度训练条件下氧化应激对血清白细胞介素-6的影响  

Effect of oxidative stress to interleukin-6 in serum and its medical significance

作　　者：吴志鸿[1] 郑静晨[2] 侯世科[3] 樊豪军[3] 唐红卫[4] 穆学涛[5] 胡红焱[5] 

机构地区：[1]中国人民武装警察部队总医院眼科,北京100039 [2]中国人民武装警察部队总医院 [3]中国人民武装警察部队总医院医务部 [4]中国人民武装警察部队总医院消化科 [5]中国人民武装警察部队总医院核磁共振室

出　　处：《中国急救复苏与灾害医学杂志》2010年第8期723-725,共3页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：武警总部课题（WZ2009001）

摘　　要：目的研究高温、高强度和阳光中紫外线照射下训练士兵血清中白细胞介素-6（IL-6）的变化。方法选择训练组和对照组士兵共60人，于训练结束后，抽取外周血。采用酶联免疫吸附测定法检测对照组和训练组血清中IL-6、活性氧（ROS）、一氧化氮（NO）、丙二醇（MDA）、超氧化物歧化酶（SOD）的表达水平。结果对照组和训练组血清中IL-6、ROS、NO、SOD表达水平比较有统计学意义（P〈0．05）；对照组和训练组血清中MDA表达水平比较差异无统计学意义（P〉0．05）。结论高温、高强度和阳光中紫外线辐射下训练，机体产生氧化应激，血清中IL-6表达水平升高。Objective To investigate the changes and the role of interleukin-6 （IL-6） of those soldiers in serum level in intensive drill under high temperature and UV radiation of sunlight. Methods 60 soldiers were evenly divided into two groupsthe drill group and the control group, and their blood from peripheral vein was collected and tested after drill . IL-6, reactive oxygen species （ROS）, nitric oxide （NO）, malondialdehyde （MDA） and superoxide dlsmutase （SOD） were detected by Enzyme Linked Immunosorbent Assay （ELISA）. Results The serum levels of IL-6, ROS, NO, SOD in the drill group were significantly higher than that in control group （all P〈0.05）. There was no significant difference in MDA between two groups （P〉0.05）. Conclusion Organism could be affected and turned to stress state and increased caused by factors as high temperature, intensive drill, and the UV radiation of sunlight. The oxidative stress leads IL-6 to increase.

关 键 词：白介素-6 自由基 高强度训练 

分 类 号：R392.12[医药卫生—免疫学]