系统性红斑狼疮合并甲状腺疾病的临床特征分析  

Clinical manifestations of systemic lupus erythamatosus associated with autoimmune thyroid disease

作　　者：李守新[1] 李晨霞[1] 关隽[1] 涂巍[1] 何培根[1] 雷小妹[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院风湿免疫科,武汉430030

出　　处：《临床内科杂志》2010年第8期536-538,共3页Journal of Clinical Internal Medicine

摘　　要：目的 调查系统性红斑狼疮（SLE）合并免疫性甲状腺疾病的年患病数,并探讨分析其临床特点.方法 回顾性调查2008年度武汉同济医院风湿免疫科住院的172例SLE病例,分析其中49例检测了甲状腺功能患者的临床资料,并分组比较SLE合并甲状腺疾病的临床特征.结果 SLE合并甲状腺功能减退症（甲减）组,17例;SLE合并甲状腺功能亢进症（甲亢）组,10例;病例对照组,22例.SLE合并甲状腺疾病的总体患病率约为15.7%,合并甲减和甲亢的患病率分别为9.89%和5.81%.多关节炎和抗ds-DNA抗体阳性检出率低是SLE合并甲减的主要特征,发热则在SLE合并甲亢的病人多见（P均＜0.05）.结论 SLE合并甲状腺疾病临床并不少见,它具有独特的临床特征,应注意监测其甲状腺功能.Objective To investigate the annual prevalence and clinical manifestations of systemic lupus erythematosus （SLE） associated with autoimmune thyroid disease. Methods The clinical features of 172 SLE patients hospitalized in Wuhan Tongji hospital during 2008 were reviewed retrospectively. A further detail was evaluated in 49 SLE patients having checked thyroid function, including free Triiodothyronine （ Fr3 ）, free thyroxine （ FT4 ） and thyroid-stimulating hormone （ TSH ）. Results 49 SLE patients were classified to have hypothyroidism, 17 cases ; hyperthyroidism, 10 cases ; and normal thyroid function,22 cases. The general prevalence of SLE patients with thyroid disease was about 15.7% , and with hypothy- roidism and hyperthyroidism was 9.89% and 5.81%, respectively. Polyarthritis and negative anti-double strain DNA antibody occurred more often in patients with hypothyroidism, but fever in hyperthyroidism （P 〈 0. 05）. Conclusion Autoimmune thyroid disease is not less common to see in SLE patients, which have distinctive clinical and immunological features. More attention to thyroid function should be paid in SLE patients.

关 键 词：红斑狼疮 系统性 甲状腺功能亢进症 甲状腺功能减退症 

分 类 号：R593.241[医药卫生—内科学]