MB麻风用MDT时组织病理与临床表现的关系  

Correlation between Pathological and Clinical Manifestations of MB Leprosy during Treatment with MDT

作　　者：马家驹 何存新 张秀莲 殷毅 门发德 孙利红 邓云山[2] 

机构地区：[1]陕西省汉中疗养院,723000 [2]西安医科大学

出　　处：《中国麻风杂志》1999年第1期13-17,共5页

摘　　要：对104例初治的 MB 麻风完成24个月的 MDT 疗程后皮肤病理、细菌和临床的变化及其间的关系,按临床转归的不同分组进行了研究;结果表明,肉芽肿分数(GF)、对数组织指数(LHI)、肉芽肿细菌密度指数(BIG)和皮肤涂片的 B1,均与 MDT 疗程呈负相关;与疗前相比,各项检测值下降均非常显著,浸润灶明显缩小,泡沫细胞退化、减少,也与疗程呈负相关。治疗24个月时临床有效率为100%,其中12.5%达到治愈标准。本组 MB 病人在完成 MDT 后,其病理、细菌和临床的改善是一致的,但以 GF 与BIG 更能稳定地反映疗效,而 GF 和 LHI 则能敏感地反映近期疗效;完成 MDT 后临床转归的不同,与治疗前病理损害的程度及菌荷量有关,其检测指数愈低者,疗效愈好。治疗后浸润灶的大小有助于疗效判定,而泡沫细胞的数量似乎与之无关。Histopathological,bacteriological and clinical changes among 104 newly detect- ed MB leprosy patients living in Hanzhong leprosary,Shaanxi,have been simultaneously ob- served months six,twelve,eighteen and twenty four after starting WHO—MDT and followed up for other two years.During the treatment all of above—mentioned three indices have syn- chronously and gradually improved as time of the treatment went on.For those who had higher BI before the treatment the improvement was slower,but by the 54 th month all of them have been cured according to the criterion in China.

关 键 词：麻风 联合化疗 组织病理 

分 类 号：R755.02[医药卫生—皮肤病学与性病学]