一种新的纤溶活性测定法及在心肌梗死中的应用  

Application of a new method for measuring fibrinolytical activity in myocardial infarction.

作　　者：黄繁嫱[1] 刘丽[1] 杨莉[1] 穆红[1] 李家增[1] 齐新[1] 刘克强[1] 

机构地区：[1]天津市第一中心医院暨天津市血栓与止血研究所

出　　处：《上海医学检验杂志》1999年第2期83-85,共3页Shanghai Journal of Medical Laboratory Sciences

摘　　要：目的：建立新的纤维蛋白溶解活性（Ｆｉｂｒｉｎｏｌｙｔｉｃａｃｔｉｖｉｔｙ，ＦＬＡ）测定方法，并初步应用于心肌梗死（ＡＭＩ）患者的观察。方法：将定量受检血浆加于含有纤溶酶原（ＰＬＧ）和标准纤维蛋白的小试管中，同时加入定量的组织纤溶酶原激活剂（ｔ－ＰＡ）、硅粒，３７℃温育一小时，检测生成Ｄ－二聚体的量。结果：４０例正常人的ＦＬＡ分级在Ⅱ－Ⅲ级（占７０％），６０例ＡＭＩ患者ＦＬＡ分级在０、Ⅰ和Ⅳ级（占７３．８％）。结论：ＦＬＡ可作为一项反映人体纤溶活性的新指标。A method to determine human fibrinolytic activity (FLA) was established and preliminary used in AMI. Add patient's plasma to fixed quantity of t PA and silica to a standardized fibrin tube containing plasminogen and incubated at 37℃ for 1 hour, then examine the D Dimer. 40 healthy persons FLA is graded on Ⅱ, Ⅲ; but 60 AMI patients is concentrated on grade 0, Ⅰ, Ⅳ(73 8%). There is individual difference in human fibrinolytic activity influenced by many factors. The FLA is an important test for evaluating the function of human fibrinolytic activity.

关 键 词：纤溶活性 D-二聚体 急性 心肌梗塞 测定 

分 类 号：R542.220.4[医药卫生—心血管疾病]