康复期海洛因依赖男性患者精神症状与视觉诱发电位P_(300)的关系  

A Study on the Relationship Between the Psychiatric Symptom and Visual Evoked Potential P_(300) in Male Patients with Heroin Dependence in Rehabilitative Period

作　　者：李武[1] 胡春凤[1] 吴大兴[2] 杜芳[1] 王桂山[1] 翟金国[1] 郝伟[2] 

机构地区：[1]山东省安康医院,山东济宁272051 [2]中南大学湘雅二医院精神卫生研究所,湖南长沙410011

出　　处：《中国临床心理学杂志》2010年第4期429-430,450,共3页Chinese Journal of Clinical Psychology

基　　金：国家重点基础研究专项经费973项目(National Basic Program of China;No:003CB515400);2004中南大学研究生教育创新工程项目(040143);山东省济宁市科技局立项课题(200732)

摘　　要：目的:探讨处于康复期的海洛因依赖男性患者(MPHD)精神症状与视觉诱发电位P300(VEP-P300)的特点及二者的关系。方法:采用抑郁自评量表(SDS)、焦虑自评量表(SAS)及症状自评量表(SCL-90),对38例MPHD与30例健康对照进行评估,并于1周内测受试前额区(Fz)、中央区(Cz)及顶区(Pz)的VEP-P300。结果:除强迫状态、人际关系外,MPHD组SCL-90总分及其各因子、SDS总分及SAS总分均显著高于对照组。MPHD组与对照组VEP-P300各指标均无显著差异。SAS、SCL-90总分及SCL-90多个因子与Fz、Cz、Pz点VEP-P300的潜伏期呈显著正相关。结论:康复期的MPHD仍存在着抑郁、焦虑情绪以及多种心身症状,心理状况与VEP-P300密切相关。Objective：To explore the feature and relationship of pathological psychology and visual evoked potential P300（VEP-P300） in male patients with heroin dependence（MPHD） in rehabilitative period.Methods：38 MPHD and 30 healthy controls were evaluated with Self-Rating Depression Scale（SDS）,Self-Rating Anxiety Scale（SAS） and Symptom Checklist 90（SCL-90）;and VEP-P300 were tested at the forehead zone（Fz）,the central zone（Cz） and the parietal zone（Pz） in the following week.Results：Compared with healthy controls,MPHD had significantly higher total scores of SDS,SAS,and higher total and factor scores of SCL-90 except factor obsession-compulsive and interpersonal sensitivity of SCL-90（P0.05 or P0.01）.When administered drug pictures as targets（DT）,there was no significant difference at Fz,Cz and Pz between MPHD and controls（P0.05）.There was significant positive correlation between the total scores of SAS,SCL-90,most factors of SCL-90 and the VEP-P300 latent period at Pz,Cz and Pz（P0.05 or P0.01）.The values of correlation were from 0.32 to 0.48.Conclusion：In rehabilitative period,MPHD still suffered from depressive,anxious mood and multitude psychosomatic symptoms,and VEP-P300 shows close correlation with psychological state.

关 键 词：海洛因依赖 视觉诱发电位P300 抑郁 焦虑 SCL-90 

分 类 号：R395.4[哲学宗教—心理学]