慢性乙肝患者与慢性乙肝病毒携带者血清抗HBc-IgM(+)检测分析  

Analysis On Detectiing Data Of Anti-HBc IgM(+) Of The Serums From Chronic Hepatitis B Patients And Chronic A-symptomatic HBV Carriers

作　　者：曾凡荣[1] 朱向秀[1] 杨光[1] 朱红艳[1] 丁君[1] 张飞[1] 

机构地区：[1]淮南市疾病预防控制中心,安徽淮南232033

出　　处：《安徽预防医学杂志》2010年第4期266-268,共3页Anhui Journal of Preventive Medicine

摘　　要：目的探讨血清抗HBc-IgM(+)在CHB与ASC中分布情况及CHB的血清抗HBc-IgM(+)与HBVD-NA的关系,为乙肝防治提供依据。方法对91例CHB与118例ASC进行ALT、AST,HBv-M及HBVDNA检测,同时进行血清抗HBc-IgM检测,探讨血清抗HBc-IgM(+)在CHB与ASC中的分布情况,并与HBVDNA检验结果做相关分析。结果53例HBeAg(+)的CHB血清抗HBc-IgM(+)者30例(56.6%),38例HBeAg(-)的CHB血清抗HBc-IgM(+)者21例(55.3%);37例HBeAg(+)的ASC血清抗HBc-IgM(+)者7例(18.9%),81例HBeAg(-)的ASC血清抗HBc-IgM(+)者6例(7.4%)。91例CHB血清抗HBc-IgM(+)总检出51例(56.0%),118例ASC血清抗HBc-IgM(+)总检出13例(11.0%)。30例血清抗HBc-IgM(+)、HBeAg(+)的CHB检出HBVDNA阳性29例(96.7%),21例血清抗HBc-IgM(+)、HBeAg(-)的CHB检出HBVDNA阳性15例(71.4%)。结论血清抗HBc-IgM(+)在CHB与ASC中有不同的分布,在CHB中血清抗HBc-IgM(+)检出与HB-VDNA阳性检出有高度相关性。Objective To explore the distribution of serum anti-HBc IgM（＋） among patients with Chronic Hepatitis B（CHB） and Chronic A-symptomatic HBV Carriers（ASC）,and the relationship between serum anti-HBc IgM（＋） of patients with CHB and HBVDNA,and provide evidence for HBV control.Methods Serum ALT,AST,HBv-M,HBVDNA and anti-HBc IgM of 91 CHB patients and 118 ASC patients were detected in order to explore the distribution of serum anti-HBc IgM（＋） in patients with CHB and ASC.And the relationship between serum anti-HBc IgM（＋） of patients with CHB and HBVDNA were analyzed by correlation analysis.Results 30 of 53 CHB patients with HBeAg（＋） was serum anti-HBc IgM（＋）（accounted for 56.6%）.21 of 38 patients of CHB with HBeAg（-） was serum anti-HBc IgM（＋）（accounted for 55.3%）.7 of 37 ASC patients with HBeAg（＋） was serum anti-HBc-IgM（＋）（accounted for 18.9%）.6 of 81 ASC patients with HBeAg（-） was serum anti-HBc-IgM（＋）（accounted for 7.4%）.The detection rates of serum anti-HBc IgM（＋） were 56.0%（51/91） in CHB patients and 11.0%（13/118） in ASC patients.The positive rate of HBVDNA was 96.7%（29/30） in CHB patients with serum anti-HBc IgM（＋） and HBeAg（＋）,and the value was 71.4%（15/21） in CHB patients with serum anti-HBc IgM（＋） and HBeAg（-）.Conclusion The distribution of serum anti-HBc IgM（＋） was different betnceen CHB and ASC,and the serum anti-HBc IgM（＋） betnceen CHB was closely correlative with HBVDNA positively.

关 键 词：血清 抗HBC-IGM 慢性乙型肝炎 乙肝病毒 携带者 

分 类 号：R512.62[医药卫生—内科学]