Notch信号通路对成年哺乳动物中枢神经系统的调控  

Notch signaling pathway regulates adult mammalian central nervous system

作　　者：赵昱[1] 马磊[1] 侯丽宏[1] 陈绍洋[1] 

机构地区：[1]第四军医大学西京医院麻醉科,西安710032

出　　处：《国际麻醉学与复苏杂志》2010年第4期343-345,352,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金资助项目（30772826）

摘　　要：生理情况下Notch通路不仅对成年神经干细胞数量的维持和自我更新发挥着决定性的作用,而且还可以抑制其向神经元分化,促进其向神经胶质细胞分化.脑缺血发生后,Notch信号通路被激活以调控缺血后脑损害区域的结构和功能重建.此文将主要综述Notch信号通路及其在生理和病理情况下对成年哺乳动物中枢神经系统的调控.Physiologically, Notch signaling pathway is not only to be implicated in the maintenance and self-renewal of adult NSC, but also can inhibit differentiation of NSC to neuron and promotes to neural glia cells. After cerebral ischemia occurs, Notch signaling pathway is activated to regulate the reconstitution of the brain lesion and functional restoration. Here, we review the roles of Notch signaling pathway in the adult mammalian CNS in physiological and pathological conditions.

关 键 词：NOTCH信号通路 神经干细胞 神经胶质细胞 分化 增殖 

分 类 号：R741[医药卫生—神经病学与精神病学]