尿激酶在动静脉内瘘血栓形成患者中应用的护理  

Application and nursing about urokinase for the treatment of thrombosis in arteriovenous fistula in hemodialysis patients

作　　者：唐春苑[1] 梁碧宁[1] 王饶萍[1] 冯婉娜[1] 王若丹[1] 王路英[1] 

机构地区：[1]中山大学附属一院肾内科血液净化中心,广州510060

出　　处：《中华现代护理杂志》2010年第22期2620-2622,共3页Chinese Journal of Modern Nursing

摘　　要：目的 观察尿激酶对血液透析患者动静脉内瘘血栓进行溶栓的疗效,探讨简单、安全、有效的溶栓方法.方法 回顾性分析本中心23例患者43例次局部注射尿激酶治疗动静脉内瘘血栓形成资料,比较溶栓前后的部分凝血活酶活化时间（APTT）、纤维蛋白原（Fbg）、国际标准化比值（INR）、凝血酶原时间（PT）、凝血酶时间（TT）.结果 23例患者共行43例次溶栓治疗,成功33例次占76.7%,未见不良反应.溶栓治疗与血栓形成的时间有关,与年龄、透析年限及内瘘使用时间无关,溶栓前后APTT、Fbg、INR、PT、TT差异无统计学意义.结论 尿激酶对动静脉内瘘溶栓治疗操作简单,创伤小,成功率较高,不良反应少,有较高的临床应用价值.Objective To observe the effects of urokinase in the treatment of thrombosis in hemodialysis patients with arteriovenous fistulae and to discuss simple, safe and effective methods of thrombolysis. Methods Local injections of urokinase were applied in 23 hemodialysis patients for 43 times to treat thrombosis in fistula, then the effects were observed, and the changes between before treatment and after treatment of several index, such as activated partial thromboplastin time（ APTT）, Fibrinogen（ Fbg）, international normalized ratio （INR）, Prothrombin Time （PT）, thrombin time（TT） were compared. Results The thrombolytic therapies were used in 23 cases for 43 times in total, in which 33 times （76.7% ） received success, and there were no severe complications occurred. The effectiveness was related to the duration of thrombosis. There were no significant differences in comparison of APTT, Fbg, INR, PT, TT before and after urokinase administration. Conclusions Urokinase was effective in thrombolytic therapy for hemodialysis patients with thrombosis in arteriovenous fistula.

关 键 词：尿激酶 动静脉内瘘 溶栓 血栓 护理 

分 类 号：R473.5[医药卫生—护理学]