基于功能近红外光谱技术(fNIRs)的帕金森病大鼠模型脑组织特性研究  

Study on Brain Tissue Characteristics of Rat Model of Parkinson'sDisease Based on Functionality Near-Infrared Spectroscopy(fNIRs) Technology

作　　者：胡光霞[1] 钱志余[1] 孙涛[2] 杨天明[3] 王文宏[3] 

机构地区：[1]南京航空航天大学生物医学工程系,江苏南京210016 [2]蚌埠医学院第一附属医院神经外科,安徽蚌埠233004 [3]东南大学附属中大医院神经外科,江苏南京210009

出　　处：《光谱学与光谱分析》2010年第9期2360-2364,共5页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(30671997)资助

摘　　要：利用功能近红外光谱技术(functionality near infrared spectroscopy,fNIRs)探索帕金森病(parkin-son′s disease,PD)大鼠模型的脑组织功能特性。通过小动物磁共振(magnetic resonance imaging,MRI)和电子计算机断层扫描(computed tomography,CT)对PD大鼠模型进行影像学研究,用fNIRs系统测试大鼠模型脑组织纹状体特征参数。实验结果表明,PD大鼠脑部没有明显的形态结构变化;优化散射系数(reducedscattering coefficient:μ′s)、脑血容量(cerebral blood volume:CBV)在PD大鼠的纹状体部与对照组间存在显著的差别;fNIRs测量参数(μ′s、CBV)与CT灌注(CTP)测定参数[CBF(cerebral blood flow),CBV]之间存在相关性。这些结果表明fNIRs可以作为PD研究的重要参考手段。Functionality near infrared spectroscopy（fNIRs） technology was utilized in the present paper to explore functional properties of brain tissue of rat model of Parkinson＇s disease（PD）.Imaging data of rat model were detected by small animal MRI and CT;and characteristic parameters of striatum of rat brain were detected by fNIRs system.Experimental results show that,between PD and normal rat,there is no obvious change in morphological structure,but significant differences existed in reduced scattering coefficient（μ′s） and cerebral blood volume（CBV） of rat striatum;there exists correlation between parameters（μ′s,CBV） obtained by fNIRs and parameters（cerebral blood flow（CBF）,CBV） obtained by CT perfusion（CTP）.These results indicate that fNIRs can be used as important reference for PD research.

关 键 词：功能近红外光谱 优化散射系数(μ′s) 脑血容量 脑组织特性 

分 类 号：R318[医药卫生—生物医学工程]