利奈唑胺注射液致血小板减少的前瞻性分析  

Prospective Analysis of Linezolid Injection-induced Thrombocytopenia

作　　者：王虎军[1] 吴雪[2] 徐琳[1] 刘静[1] 李勇[1] 

机构地区：[1]北京军区总医院药理科,北京市100700 [2]解放军181医院药剂科,桂林市541002

出　　处：《中国药房》2010年第34期3229-3231,共3页China Pharmacy

摘　　要：目的:对利奈唑胺注射液致血小板减少进行前瞻性分析。方法:对我院2008～2009年因病情需要使用利奈唑胺注射液的重症感染患者(42例),进行前瞻性研究分析,重点分析该药引起血小板不良反应的发生率。结果:排除患者本身有血液系统疾病的病例14例,使用利奈唑胺注射液后血小板数呈下降趋势的占71.43%,其中下降至异常的占21.43%,停药后6～10d全部自行恢复。结论:利奈唑胺在用药前、后应检查或监测全血细胞计数,停药后大多患者血小板数可自行恢复。OBJECTIVE：To analyze Linezolid injection-induced thrombocytopenia prospectively.METHODS：42 severe infectious patients who were treated with Linezolid injection in our hospital from 2008 to 2009 were analyzed prospectively,especially the incidence rate of adverse effect on platelet.RESULTS：Except for 14 patients with hematological systemic disease,the proportion of patients whose platelet was downtrend after giving Linezolid injection was 71.43%.Among them patients whose platelet descended to abnormal level accounted for 21.43%.The parameters had risen towards pretreatment levels 6～10 days after drug withdrawal.CONCLUSION：The complete blood count should be monitored before and after the application of linezolid.In most of cases the parameters of platelet return to pretreatment levels after drug withdrawal.

关 键 词：利奈唑胺 不良反应 血小板减少 前瞻性分析 

分 类 号：R969.3[医药卫生—药理学] R978.1[医药卫生—药学]