甲基叔丁基醚的急性毒性研究  

Acute Toxcity Studies On Methyl Tertiary Butyl Ether(MTBE)

作　　者：赵进顺[1,2] 黄关麟 田世兰[1,2] 张恒 

机构地区：[1]南京铁道医学院预防医学系 [2]南京炼油厂职工医院

出　　处：《中国公共卫生》1999年第3期264-265,共2页Chinese Journal of Public Health

摘　　要：为研究国产甲基叔丁基醚（ＭＴＢＥ）的毒性，比较与国外产品的异同，选用大、小鼠及家兔，采用经口、呼吸道及皮肤等染毒途径，同时对国产及进口ＭＴＢＥ的急性毒性进行研究，结果表明：国产及进口ＭＴＢＥ的小鼠经口ＬＤ５０分别为２９４５．２和２９４４．４ｍｇ／ｋｇ，大鼠均为３４３３．６ｍｇ／ｋｇ。小鼠经呼吸道ＬＣ５０分别为７２９８８．３和９９６３０ｍｇ／ｍ３，大鼠为８５３２０和１０３４１０ｍｇ／ｍ３。急性中毒表现均为先兴奋，然后出现粘膜刺激症状，运动失调，活动减少，麻醉，最后死亡。兔经皮染毒仅见脱脂现象，无致炎、致敏或中毒作用。但对兔眼睛有较强致炎作用。结论：国产或进口ＭＴＢＥ的动物经口或经呼吸道急性毒性基本相同，均属低毒物，经皮属微毒物。In order to study the acute toxicities of MTBE.Two MTBE samples(made in China and German)were studied.The acute toxicities were conducted with mice,rats or rabbits,through oral,inhalation or dermal contaminations.Rsults show that,in mice,LD 50 of China and German samples are 2945 2 and 2944 4mg/kg;in rats,both are 3433 6mg/kg,LC 50 of mice are 72988 3 and 99630mg/m 3,and LC 50 of rats are 8530 and d103410mg/m 3 respectively.Clinical symptoms of acute toxicities include sedation,ocular and mucous membrane irritation,ataxia,hypoactivity and ansthesica etc.There are no irritation or toxicity to be find throughdermal contamination.But there is a significant irritating tothe rabbits'eyes.Conclutions;there are no signkficant differences about acute toxicities between China and German MTBE samples.Both belong to a lower toxicity substance through oral or inhalation contaminations,anda slight toxicity subtance through dermal.But,both have a significant irritating to rabbits'eyes.

关 键 词：甲基叔丁基醚 急性毒性 半数致死量 毒性 

分 类 号：R995[医药卫生—毒理学]