虎杖有效成分3,4′,5-三羟基芪-3-β-D-葡萄糖苷的研究进展  

Advances in research on 3,4′,5-trihydrostilbene-3-β-D-glucoside,an effective component from Polygonum cuspidatum Sieb.et Zucc

作　　者：骆苏芳[1] 金行中[1] 叶建锋 张佩文 

机构地区：[1]第一军医大学基础部毒理学教研室

出　　处：《中国药理学与毒理学杂志》1999年第1期1-4,共4页Chinese Journal of Pharmacology and Toxicology

摘　　要：总结了虎杖有效成分３，４′，５－三羟基芪－３－β－Ｄ－葡萄糖苷（虎杖晶Ⅳ）近１０年来的研究，评价了虎杖晶Ⅳ在防止动脉内皮损伤性血栓形成，改善休克微循环，提高休克大鼠存活率，减轻缺血再灌注，自由基，内毒素等造成的组织器官损伤，降血脂及抗脂质过氧化等方面的作用．提示虎杖晶Ⅳ可能成为治疗血栓性疾病及改善休克微循环等方面一个有特色的新药．The advances in recent 10 years in research on 3,4′,5 trihydrostilbene 3 β D glucoside (polydatin), a effective component from Polygonum cuspidatum Sieb. et Zucc., were summarized in this paper. The actions of polydatin, such as preventing thrombosis from arterial endothelial damage, improving microcirculation and increasing survival rate of shocked rats, alleviating tissue organ damage induced by ischemia reperfusion, oxygen free radical and endotoxin, decreasing hyperlipemia, suppressing lipid peroxide and so on were evaluated. The review displays the pharmacologic base of polydatin in treatment of thrombotic diseases and improvement of microcirculation in shock, which enable polydatin to become a new characteristic drug.

关 键 词：3 4′ 5-三羟基芪-3-β-D-葡萄糖苷 血栓形成 血小板聚集 血栓烷类 依前列醇 微循环 局部缺血 脂质过氧化作用 

分 类 号：R284.1[医药卫生—中药学] R285.5[医药卫生—中医学]