二甲基阿米洛利对大鼠油酸性急性肺损伤的保护作用  

Protection of dimethyl amiloride against acute lung injury induced by oleic acid in rats

作　　者：罗健东[1] 郑平香[1] 

机构地区：[1]广州医学院药理学教研室

出　　处：《中国药理学与毒理学杂志》1999年第1期73-74,共2页Chinese Journal of Pharmacology and Toxicology

摘　　要：呼吸窘迫综合征（ｒｅｓｐｉｒａｔｏｒｙｄｉｓｔｒｅｓｓｓｙｎｄｒｏｍｅ，ＲＤＳ）是一种死亡率高达５０％以上的以肺泡毛细血管损伤为特征的疾病［１］．油酸（ｏｌｅｉｃａｃｉｄ，ＯＡ）性肺损伤动物模型产生与ＲＤＳ病人相似的表现，已被广泛用于ＲＤＳ发病机理和...The effect of Na +/H + exchange inhibitor dimethyl amiloride(DMA) on rat acute lung injury induced by oleic acid was studied. Five hours after administration (iv) of oleic acid (10 mL·kg 1 ), pulmonary coefficient, lung wet/dry weight ratio and protein content, lactic acid dehydrogenase(LDH) activity, total white blood cell(WBC) and polymorphonuclear leukocyte(PMN) in bronchoalveolar lavage(BAL) of rat were increased significantly. However, after pretreatment with DMA(0.2 mg·kg 1 iv) for 10 min, the pulmonary coefficient and lung wet/dry weight ratio were decreased from 1.12±0.06 to 0.87±0.05 and 5.8±0.5 to 4.5±0.3, respectively. The protein content, LDH activity, total WBC and PMN in BAL were also reduced from (1.69±0.15) g·L 1 to (1.05±0.13) g·L 1 , (3.37±0.25) μmol·min 1 ·L 1 to (0.81±0.08) μmol·min 1 ·L 1 , (4.3±0.9) ×10 6·L 1 to (2.4±0.8) ×10 6·L 1 and (2.4±0.4) ×10 6·L 1 to (1.6±0.4) ×10 6·L 1 , respectively. These results suggest that activation of Na +/H + exchange be involved in the acute rat lung injury induced by oleic acid and that inhibitor of sodium hydrogen exchange prevent the rat lungs from this injury.

关 键 词：二甲基阿米洛利 肺损伤 急性 油酸性 保护作用 

分 类 号：R974[医药卫生—药品]