大鼠脑内白细胞介素1I型受体mRNA的分布  

DISTRIBUTION OF NEURONS EXPRESSING INTERLEUKIN-1 TYPE I RECEPTOR mRNA IN RAT BRAIN

作　　者：刘国法[1] 吕证宝[2] 安林[2] 

机构地区：[1]扬州大学医学院解剖学教研室,扬州225001 [2]北京医科大学细胞生物学教研室,北京100083

出　　处：《解剖学杂志》1999年第1期27-30,共4页Chinese Journal of Anatomy

摘　　要：目的 :研究大鼠脑内白细胞介素 1I型受体 m RNA表达神经元的分布。材料和方法 :以 35S标记的 IL- 1Rt Ic DNA作为探针 ,采用原位杂交技术检测大鼠脑内 IL- 1Rt I m RNA表达神经元分布广泛而又不均匀。根据表达IL- 1Rt I m RNA神经元的密度变化 ,大鼠脑可分为四种密度区 :非常高、高、中等、低密度区。结论 :提示脑内白细胞介素 1通过其Objective:To study the distribution of neurons expressing IL 1 RtI mRNA in rat brain. Materials and Methods: IL 1 RtI cDNA was used as a probe to evaluate the expression of IL 1 RtI mRNA in Wistar rat brain by in situ hybridization. Results: The neurons expressing IL 1 RtI mRNA distributed distinctively and widespread in rat brain. According to the density of the neurons containing IL 1 RtI mRNA, the rat brain could be divided into four degrees: very high, high, median, and low density areas. Conclusion: The results suggest that the function of IL 1 may be mediated by the IL 1 type I receptor in the brain.

关 键 词：脑 白细胞介素1 I型受体 MRNA 分布 大鼠 

分 类 号：Q593.2[生物学—生物化学] R329.28[医药卫生—人体解剖和组织胚胎学]