胶原/PLLA纳米粒子复合海绵的制备及其生物相容性评价  

Hybrid porous scaffold derived from collagen and PLLA nanoparticles

作　　者：卢伟[1] 冯玉杰[1] 岩小丽[1] 樊渝江[1] 

机构地区：[1]四川大学国家生物医学材料工程技术研究中心,成都610064

出　　处：《中国实用医药》2010年第25期13-14,共2页China Practical Medicine

基　　金：国家863计划重大项目资助研究课题(项目编号:2006AA02A125)

摘　　要：通过紫外和自由基聚合在PLLA上接枝聚丙烯酸(PAA),制备了平均粒径316nm,zeta电位-39.88mV的表面亲水性PLLA纳米粒子,与胶原溶液混合通过冷冻干燥法制备了胶原/PLLA纳米粒子复合多孔支架。复合支架材料的孔隙率与纯胶原支架相近,而密度、湿态压缩模量有明显提高,降解率降低显著。随着复合支架中PLLA纳米粒子的增加,L929细胞在材料中的播种效率和增殖有明显提高,表明胶原/PLLA纳米粒子复合多孔支架是一种理想的组织工程支架材料。Poly （ acrylic acid） was grafted on PLLA through UV radiation,and PLLA nano-particles were prepared. Then collagen/PLLA nano-particle hybrid sponge was fabricated. The porosity of hybrid sponge was similar with that of collagen sponge,whereas density and wet modulus were improved,and the degradation was largely inhibited. The cell seeding efficiency and proliferation on the hybrid sponge was obviously promoted,indicating that the hybrid sponge was promising in tissue scaffold.

关 键 词：胶原 PLLA纳米粒子 支架材料 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]