慢性丙型肝炎患者血清白介素-8表达水平与基因型及抗病毒治疗的相关性  

Relationship of expression level of serum IL-8 with HCV genotypes and antivirus treatment in patients with chronic hepatitis C

作　　者：张立新[1,2] 安勇[2] 徐皖苏[3] 张孝国[2] 刘靓雯[3] 于进红[2] 张琴冈[2] 

机构地区：[1]山东大学医学院,济南250012 [2]济南市传染病医院肝病科,济南250021 [3]济南市传染病医院中心实验室,济南250021

出　　处：《山东大学学报（医学版）》2010年第8期100-102,共3页Journal of Shandong University:Health Sciences

基　　金：济南市卫生局资助项目(2005-83)

摘　　要：目的探讨慢性丙型肝炎患者血清白介素-8(IL-8)水平与丙型肝炎病毒(HCV)感染、基因型及抗病毒治疗的关系。方法对74例慢性丙型肝炎患者应用基因芯片法进行基因型检测,应用双抗体夹心ABC-ELISA法检测患者血清IL-8。比较不同基因型患者之间IL-8水平的差别,观察了抗病毒治疗12周后IL-8水平的变化。结果慢性丙型肝炎患者及健康对照组血清IL-8水平分别为(42.95±50.00)pg/mL及(11.06±1.39)pg/mL(P<0.01);基因1b型慢丙肝患者(46例)及基因2a型患者(28例)IL-8水平分别为(52.72±60.67)pg/mL及(26.93±13.97)pg/mL(P<0.05)。抗病毒治疗后HCV RNA转阴者,其IL-8水平由(41.20±25.89)pg/mL降至(23.89±10.59)pg/mL(P<0.01)。结论慢丙肝患者血清IL-8水平较健康对照组明显升高,且以感染HCV基因1b型者更明显。抗病毒治疗HCV RNA阴转后,其IL-8水平明显回降。Objective To study the relationship of expression level of serum interleukin-8（IL-8） and HCV genotypes in patients with chronic hepatitis C and observe the change of serum IL-8 level after antivirus treatment.Methods HCV genotypes were determined using DNA chip assay in 74 chronic hepatitis C patients.Serum IL-8 of these patients was determined using bi-antibody sandwich ABC-ELISA assay.Levels of IL-8 in chronic hepatitis C patients with different genotypes were compared.The change of IL-8 level after 12 weeks of antivirus treatment was observed.Results Levels of serum IL-8 in chronic hepatitis C patients and healthy controls were（42.95±50.00）pg/mL and（11.06±1.39）pg/mL,respectively（P0.01）,and in patients infected with genotype 1b and genotype 2a were（52.72±60.67）pg/mL and（26.93±13.97）pg/mL,respectively（P0.05）.After 12 weeks of antivirus treatment,the serum IL-8 level in patients with undetectable HCV RNA decreased from（41.20±25.89）pg/mL to（23.89±10.59）pg/mL（P0.01）.Conclusions The serum level of IL-8 in patients with chronic hepatitis C significantly increases compared with that in healthy controls.The IL-8 level in patients with genotype 1b is higher than that in patients with genotype 2a.The IL-8 level in patients with undetectable HCV RNA significantly decreases after antivirus treatment.

关 键 词：肝炎 丙型 慢性 白介素-8 基因型 抗病毒治疗 

分 类 号：R512.6[医药卫生—内科学]