单纯高脂血症患者非药物干预的疗效评价  

Effect of non-pharmacotherapy in decreasing the levels of serum lipids in simple hyperlipidemia patients

作　　者：张敏[1,2] 徐贵发[1] 

机构地区：[1]山东大学公共卫生学院,济南250012 [2]青岛市市立医院东院区体检中心,山东青岛266071

出　　处：《山东大学学报（医学版）》2010年第8期117-119,共3页Journal of Shandong University:Health Sciences

摘　　要：目的探讨单纯高脂血症患者行非药物干预的降脂效果。方法将1 600例健康体检人员中检出的单纯高脂血症患者197例随机分为干预组99例和对照组98例,干预组给予综合性非药物干预,包括健康宣教、饮食指导、运动处方等,每周进行回访监督,对照组不进行上述干预,不服用降脂药物,在观察期开始及6个月观察期满时,分别采用酶法测定血中甘油三酯(TG)、总胆固醇(TC)和低密度脂蛋白(LDL-C)的水平变化,同时测试高脂血症相关知识知晓率、统计平均每周主动锻炼次数、估算平均每天食用油量,测定体质量指数(BMI)并进行统计学分析。结果干预组高脂血症相关知识知晓率、每周主动体育锻炼次数均有明显增加,两者增幅均高于对照组,干预组食油量明显下降,BMI下降,降幅均大于对照组(P<0.05)。干预组TG从(2.81±1.32)mmol/L降至(2.06±0.91)mmol/L,TC从(6.67±0.93)mmol/L降至(5.49±0.95)mmol/L,LDL-C从(4.69±0.89)mmol/L降至(3.83±1.02)mmol/L,与对照组相比,P值分别为0.007、0.005、0.006,各指标下降幅度均有统计学差异。而且血脂下降与相关健康知识知晓水平的提高、主动性体育锻炼的增加以及食油摄入量的减少呈明显相关性。结论非药物干预方法对单纯高脂血症患者有一定疗效,可作为单纯高脂血症患者的非药物治疗方法。Objective To investigate a non-pharmacotherapy program for patients with simple hyperlipidemia diagnosed in health examination and assess its effectiveness.Methods 197 patients were randomly divided into two groups： the experimental group（99 cases） and the control group（98 cases）.The experimental group was given non-pharmacotherapy once a week and the therapy lasted for 6 weeks.The content of non-pharmacotherapy consisted of： a） teaching related knowledge about hyperlipidemia;b） guiding a healthy life-style,such as diet and exercise.Patients were followed-up every week.The control group did not undergo any non-pharmacotherapy program.A self-completion questionnaire on hyperlipidemia-related knowledge,questionnaires on diet and exercise were obtained and serum TG,TC,LDL-C and BMI were measured at the entry point and at the end of 6month study.Results The hyperlipidemia-related knowledge and weekly physical exercise time of the experimental group increased while the daily oil intake and BMI decreased.The mean of serum TG,TC and LDL-C of the experimental group were significantly lowered compared to the control group.The TG lowered from（2.81±1.32）mmol/L to（2.06±0.91）mmol/L,TC from（6.67±0.93）mmol/L to（5.49±0.95）mmol/L,LDL-C from（4.69±0.89）mmol/L to（3.83±1.02）mmol/L,and all the differences above were significant.The decline of serum lipids was related to the increase of hyperlipidemia-related knowledge,exercise frequency and the decrease of oil intake.Conclusion Non-pharmacotherapy is effective for patients with simple hyperlipidemia and it can be used as basic therapy.

关 键 词：高脂血症 非药物干预 健康宣教 运动疗法 饮食指导 

分 类 号：R589.2[医药卫生—内分泌]