α_2β_1整合素Bg1 Ⅱ基因多态性与糖尿病合并冠心病的相关性  

Correlation between Bg1 Ⅱpolymorphism of α_2β_1 integrin gene and type 2 diabetes with coronary heart disease

作　　者：王尧[1] 胡艳红[1] 孙子林[1] 余江毅[2] 

机构地区：[1]东南大学附属中大医院内分泌病科,南京210009 [2]江苏省中医院内分泌病科

出　　处：《江苏医药》2010年第15期1741-1744,共4页Jiangsu Medical Journal

基　　金：江苏省科技厅资助项目(BS2003056)

摘　　要：目的探讨α2β1整合素基因多态性与糖尿病合并冠心病、血脂异常之间的关系。方法采用PCR-RFLPs法,对217例南京地区2型糖尿病(T2DM)患者[合并冠心病101例(A组),无冠心病116例(B组)]和107例正常对照者(C组)进行整合素α2β1Bg1Ⅱ酶切位点多态性研究,并根据冠状动脉造影结果分组分析。结果 (1)A组Bg1Ⅱ+/+基因型(56%)显著高于B组(23.3%)和C组(39.3%)(P<0.01);Bg1Ⅱ基因阳性率与冠心病冠脉病变支数呈正相关趋势;(2)Bg1Ⅱ+/+型者胰岛素抵抗指数(HOMA-IR)明显高于Bg1Ⅱ+/-及Bg1Ⅱ-/-者(P<0.05),而胰岛素敏感指数(ISI)降低;(3)不同Bg1Ⅱ基因型的各亚组间血浆总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平没有显著性差异(P>0.05)。结论α2β1整合素Bg1Ⅱ酶切位点多态性与冠状动脉病变间存在相关性,可能与T2DM胰岛素抵抗、动脉粥样硬化进展有关。Objective To investigate the correlation between α2β1 integrin gene polymorphism and the type 2 diabetes mellitus（T2DM） with coronary artery disease（CAD） or dyslipidemia.MethodsRestriction site polymorphism of α2 β1 integrin Bg1Ⅱ gene of 217 T2DM cases[101 cases with CAD（group A） and 116 cases without CAG（group B）] and 107 cases of normal controls（group C） in Nanjing were examined by PCR-restriction fragment length polymorphism technique.All data were analyzed according to the results of coronary angiography.Results （1）Bg1 Ⅱ＋/＋ genotype frequency of group A（56%） was significantly higher than that of group B（23.3%） and group C（39.3%）（P 0.01）.There was a positive correlation between the positive rate of Bg1Ⅱ gene and the amount of impaired coronary arteries.（2）Insulin resistance index （HOMA-IR） was apparently higher,insulin sensitivity index（ISI） was lower,in T2DM patients with Bg1 Ⅱ＋/＋ genotype than those with Bg1 Ⅱ＋/-or Bg1 Ⅱ-/-genotype（P 0.05）.（3）There were no illustrious differences in plasma total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein cholesterol（LDL-C） and high-density lipoprotein cholesterol（HDL-C） of T2DM patients with different Bg1 Ⅱ genotypes（P 0.05）. Conclusion There is a correlation between the restriction site polymorphism of α2 β1 integrin Bg1 Ⅱ gene and CAG,which may be associated with insulin resistance and the progression of atherosclerosis.

关 键 词：整合素 糖尿病 冠心病 

分 类 号：R587[医药卫生—内分泌]