血液净化方式对血清糖基化终产物和β_2-微球蛋白的清除效果  

Outcomes of blood purification on clearance of serum advanced glycation end products and beta 2-microglobulin

作　　者：罗宇鸿[1] 李赟[2] 李美秀[2] 付俊[3] 向允禧[2] 刘鸿[2] 

机构地区：[1]无锡市中医医院ICU,214001 [2]江西省人民医院肾脏病科 [3]上高县人民医院检验科

出　　处：《江苏医药》2010年第15期1755-1757,共3页Jiangsu Medical Journal

基　　金：江西省卫生厅课题(20081003)

摘　　要：目的探讨血液净化方式对维持性血液透析患者血清糖基化终产物(AGEs)和β2-微球蛋白(β2-MG)的清除效果。方法 48例维持性血液透析患者均分为3组,分别采用血液透析(HD组)、血液透析滤过(HDF组)、血液灌流+血液透析(HP+HD组)治疗,检测单次治疗前后血清AGEs和β2-MG,分析清除效果。结果单次HDF、HP+HD治疗后血清AGEs、β2-MG水平较透析前均明显下降(P<0.05)。透析后HDF、HP+HD组血清AGEs、β2-MG水平明显低于HD组(P<0.05)。结论透析方式是影响尿毒症患者血清AGEs、β2-MG水平的主要因素。HDF、HP+HD对AGEs、β2-MG清除作用明显优于HD治疗。Objective To compare the clearance efficacy of purification medhods on serum advanced glycation end products（AGEs）and beta2-microglobulin（β2-MG）.Methods Forty-eight patients on maintenance hemodialysis were divided randomly into three groups of hemodialysis（group HD）,hemodiafiltration（group HDF） and hemoperfusion plus hemodialysis（group HP＋HD） with 16 cases each.Serum AGEs and β2-MG were measured before and after single blood purification.The efficacy of clearance was analysed.Results Serum levels of AGEs and β2-MG were lower after blood purification than those before in groups of HDF and HP＋HD（P〈0.05）,which were lower in groups of HDF and HP＋HD than those in group HD（P〈0.05）.Conclution The methods of blood purification in uremia patients are the main factors for reducing serum AGEs and β2-MG,of which HDF or HP＋HD is better than HD.

关 键 词：糖基化终产物 Β2-微球蛋白 血液净化 

分 类 号：R692[医药卫生—泌尿科学]