人乳头瘤病毒基因亚型分布及意义  

Distribution and clinical significance of human papilloma virus genotypes

作　　者：杨挺[1] 浦洁[1] 谢平[2] 

机构地区：[1]无锡市人民医院皮肤科,214023 [2]无锡市人民医院中心实验室,214023

出　　处：《江苏医药》2010年第15期1778-1780,共3页Jiangsu Medical Journal

摘　　要：目的了解HPV基因亚型的分布状况。方法采用基因分型芯片方法检测23种基因亚型。高危型18种:HPV16,18,31,33,35,39,45,51,52,53,56,58,59,66,68,73,83,MM4和低危型5种:HPV6,11,42,43,44。结果尖锐湿疣组阳性率为95.4%,下生殖道炎症组阳性率为24.2%。检出率最高依次为11型、6型、16型。30.1%患者存在多重感染。下生殖道炎症组的高危型检出率和高危型多重感染率均高于尖锐湿疣组(P<0.05)。结论 HPV11、6、16型感染是HPV的主要型别,且HPV感染趋于多重化。下生殖道炎症患者更易受到HPV高危型感染。Objective To investigate the distribution of human papilloma virus（HPV） genotypes.Methods With DNA chip technique,23 genotypes were tested in 175 out-patients,which were 18 high-risk genotypes of HPV-16,18,3l,33,35,39,45,51,52,53,56,58,59,66,68,73,83,MM4 and 5 low-risk genotypes of HPV-6,11,42,43 44.Results The positive rates of condyloma acuminate（group CA） and lower genital tracts inflammation（group LGTI） were 95.4% and 24.2%.The most common genotypes were HPV-11,6 and 16.The multi-HPV-genotype infection rate was 30.1%.Detection rate and multiple-genotype infection rate of high-risk genotype in group LGTI were higher than those in group CA（P〈0.05）.Conclusion HPV-11,6,16 are the important genotypes for HPV.Patients with HPV infection showed a tendency of multiple-genotype infection.HPV high-risk genotypes are easier to infect the patients with lower genital tracts inflammation.

关 键 词：尖锐湿疣 下生殖道炎症 人乳头瘤病毒 

分 类 号：R373[医药卫生—病原生物学]