前列腺素E_1对大鼠睾丸扭转损伤的保护作用  

Experimental study on effects of PGE1 on testis torsion

作　　者：王洪华[1] 俞红英[1] 周小金[1] 胡玲卿[1] 龚健[1] 项静英[1] 熊芳[1] 

机构地区：[1]无锡市妇幼保健院,214002

出　　处：《江苏医药》2010年第15期1808-1810,F0002,共4页Jiangsu Medical Journal

摘　　要：目的探讨前列腺素E1对睾丸生精功能保护作用。方法建立大鼠睾丸扭转损伤的病理模型。45只大鼠随机分成3组,每组15只。A组为假手术对照组;B组大鼠睾丸扭转720度,维持2h复位,并用前列腺素E145μg·kg-1.d-1治疗;C组损伤同B组,但不予治疗。所有大鼠在手术后40d处死,取睾丸组织,肉眼观察其形态,测量长度,称其重量,计算脏器系数,行常规HE染色后镜下观察睾丸的病理改变。结果 B组睾丸长度明显长于C组[(1.99±0.07)cmvs.(1.79±0.21)cm],C组睾丸长度明显短于A组[(1.79±0.21)cmvs.(2.16±0.12)cm](P<0.05)。镜下观察:B组损伤明显轻于C组。脏器系数:B组与A组相仿,但明显大于C组[(11.98±0.89)vs.(7.86±1.07)](P<0.05)。结论前列腺素E对睾丸生精功能有明显保护作用。Objective To study the effects of prostaglandin E1 （PGE1 ） on reproduction function of the testis following torsion.Methods Forty-five rats were randomly divided into three groups with 15 rats each.The rats in group A were taken as sham operation controls.The testis-njuried model was established by making 720 degrees torsion of the testis for 2 h in group B（treated with PGE1 45 μg·kg-1 ·d-1 after restoration of the testis） and in group C（without any treatment）.Forty days later,all rats were killed and the testis was taken out and weighted for calculating organ coefficient and pathological examination.Results The length of the testis was longer in group B than that in group C [（1.99±0.07） cm vs. （1.79±0.21） cm],which was shorter in group C than that in group A [（1.79±0.21） cm vs. （2.16±0.12） cm]（P〈0.05）.The pathological changes of the testis structure in groups of A and C were similar,which were much lighter in group B than those in group C.The organ coefficient of group B was similar to that of group A,but greater than that of group C [（11.98±0.89） vs.（7.86±1.07）]（P〈0.05）.Conclusion PGE1 has remarkable protective effects on testicular spermitagnesis function.

关 键 词：前列腺素E1 睾丸 

分 类 号：R697[医药卫生—泌尿科学]