正常成年人颞叶扣带回后部MR波谱与年龄的相关性研究  

Correlation Investigation of MRS with Age in the Posterior Cingulated Gyrus of the Temporal Lobe of Healthy Adult

作　　者：蔡志强[1] 水淼[1] 沈其君[2] 王海涛[1] 

机构地区：[1]宁波大学医学院附属医院放射科,浙江宁波315020 [2]宁波大学医学院卫生统计教研室,浙江宁波315020

出　　处：《实用放射学杂志》2010年第8期1093-1095,1099,共4页Journal of Practical Radiology

摘　　要：目的 采用氢质子磁共振波谱（1H-MRS）分析探讨正常成年人年龄对颞叶扣带回后部脑组织代谢物浓度的影响.方法 选出79例无精神神经等疾病经颅脑MRI检查阴性的正常人分成4组：〈45岁（16例）,45～54岁（22例）,55～64岁（29例）,＞64岁（12例）;测量双侧颞叶扣带回后部脑组织内N-乙酰基天门冬氨酸（NAA）、肌酸（Cr）、胆碱复合物（Cho）、肌醇（mI）的浓度及NAA/ Cr、Cho/Cr、mI/Cr比值.组间比较采用方差分析,年龄与检测指标间的相关分析采用简单相关和偏相关分析法.结果 颞叶扣带回后部NAA/Cr比值在4个年龄组间差异有统计学意义（P〈0.001）;组间两两比较表明,〈45岁组与其他年龄组间差异有统计学意义（P〈0.05）,〈45岁组颞叶扣带回后部NAA/Cr最高.NAA、Cr、Cho、mI的浓度及Cho/Cr、mI/Cr比值在各年龄组差异无统计学意义.相关性分析显示NAA浓度及NAA/ Cr比值与年龄呈负相关（偏相关系数分别为r=-0.4304,P=0.0001;r=0.4895,P〈0.0001）,随年龄增大NAA浓度及NAA/Cr比值减低. mI/Cr比值与年龄呈正相关（偏相关系数r=0.3400,P=0.0030）,随年龄增大mI/Cr比值增高.结论 正常成年人颞叶扣带回后部神经元数量与活性随年龄增大减低,髓鞘退变及胶质增生随年龄增大而增高.Objective To analyse the influence of age in healthy adults on brain metabolic concentrations in the posterior cingulated gyrus of the temporal lobe by proton magnetic resonance spectroscopy（^1H--MRS）. Methods The brain metabolic concentra- tions of N-acetyl aspartic acid（NAA）, creatine（ Cr）, choline（ Cho）, Myo-inositol（ ml） and the proportionality of NAA/Cr, Cho/Cr, MI/Cr in the posterior cingulated gyrus of the temporal lobe in 79 cases which were divided to four different age group without mental and nerves disorders and without positive findings on the brain MRI were measured at 1 H-MRS and compared between 4 groups using the analysis of variance and the correlation analysis was adopted to explore the relationship between the metabolic concentrations and age. Results There were statistically differences in NAA/Cr of the posterior cingulated gyrus of the temporal lobe among the four age groups{P〈0. 001 ） and between 〈45 years group and the other three groups（P〈0.05）, the proportinomality of NAA/ Cr in 〈45 years group was higher than that in the other three age groups. There were no statistically differences in the concentrations of NAA,Cr,Cho, mI and the proportionality of Cho/Cr, mI/Cr between the four age groups. There was negative correlation between the concentration of NAA, NAA/Cr and age（ coefficient of partial correlation r=-0. 4304, P= 0. 0001 ;r= -0. 4895, P〈0. 0001）, the concentration of NAA and NAA/Cr decreased with aging. There was obviously positive correlation between mI/Cr and age （coefficient of partial correlation r= 0. 3400,P= 0. 0030 ） ,the mI/Cr increased with aging. Conclusion The quantity and activity of nerve celt decrease with aging,while medullary sheath degeneration and gliosis increase with aging in the posterior cingulated gyrus of the temporal lobe in healthy adult.

关 键 词：脑 磁共振波谱 代谢 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R445.2[医药卫生—基础医学]