外阴上皮内非瘤样病变患者病变组织中性激素受体的检测及意义  

Detection of Sexual Hormone Receptor in Pathologic Tissues of Nonneoplastic Epithelial Disorders of Vulva

作　　者：张峻霄[1,2] 何群英[3] 王世阆[1] 

机构地区：[1]四川大学华西第二医院,四川成都610041 [2]海南医学院附属医院妇产科,570101 [3]西安交通大学第一附属医院,陕西西安710061

出　　处：《实用妇产科杂志》2010年第8期598-600,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:研究外阴上皮内非瘤样病变与性激素受体(SHR)的关系。方法:采用直接荧光法,测定22例外阴上皮内非瘤样病变患者病变组织的SHR,并对其中10例进行外阴未发病组织SHR对照检测。22例中鳞状上皮增生12例,硬化性苔癣6例,硬化性苔癣合并鳞状上皮增生4例。结果:①患者病变组织及未发病组织表皮各层及真皮层内均有不同程度的雌激素受体(ER)、孕激素受体(PR)、雄激素受体(AR)阳性率;②外阴病变组织及未发病组织表皮各层间ER、AR阳性率的差异有高度统计学意义(P<0.01),均以基底层受体阳性率最低。结论:客观说明外阴是性激素的靶器官之一,为临床应用丙酸睾丸酮能缓解硬化性苔癣患者临床症状提供了理论依据。基底层SHR缺少,推测这是应用性激素不能完全治愈本病的主要原因所在。Objective. To study the relationship between nonneoplastic epithelial disorders of vulva and sexual hormone receptor （SHR）. Methods,22 patients with nonneoplastic epithelial disorders of vulva （including 12 cases of squamous hyperplasia, 6 cases of lichen sclerosus and 4 cases of mixed type） were enrolled in this study and the SHR in pathologic tissues were detected by direct fluorescence analysis. 10 of 22 cases were detected the SHR in non-pathologic tissues as control. Results：① There were different positive expressions of estrogen receptors （ER）, androgen receptors （AR） and progestin receptors （PR） in different layers of dermis and epidermis both in pathologic and non-pathologic tissues. ②There was significantly statistic difference between positive expression of ER and AR in different layers of epidermis of pathologic or non-pathologic tissues, which was obviously lower in basal layer. Conclusions：Vulva is one of the target organs of sexual hormone. The results offer an evidence for treatment of lichen sclerosus with androgen to relieve the symptom. The absence of SHR in basal layer may be a possible cause that the disease can not be cured by sexual hormone.

关 键 词：外阴上皮内非瘤样病变 雌激素受体 雄激素受体 孕激素受体 

分 类 号：R711.72[医药卫生—妇产科学]