急性大面积肺血栓栓塞症患者心肌肌钙蛋白I水平的临床研究  

Cardiac Troponin I Level of Patients with Acute Massive Pulmonary Embolism

作　　者：尹娟[1] 刘永强[2] 张泽明[1] 阎琦[1] 

机构地区：[1]河北大学附属医院,河北省保定市071000 [2]河北保定市脑血管病医院

出　　处：《中国全科医学》2010年第25期2821-2822,共2页Chinese General Practice

摘　　要：目的了解急性大面积肺血栓栓塞症(acute massive pulmonary embo-lism,AMPE)患者心肌肌钙蛋白I(CtnI)的变化情况。方法选择我院近6年确诊为急性肺血栓栓塞症(Acute pulmonary thromboem bolism,APTE)并行CtnI检查的患者共58例,其中AMPE患者19例,非AMPE患者39例,比较两组APTE患者CtnI的浓度以及血气分析、右心功能、预后情况。并对AMPE患者血浆中CtnI不同时间的平均检测值进行分析。结果 AMPE组与非AMPE组CtnI值、血气分析、右心功能以及预后方面差异有统计学意义(P<0.05)。对AMPE组(15例)患者的CtnI进行监测,发现在5h后CtnI即出现阳性反应(CtnI≥0.1μg/L),在20h左右处达到峰值。结论 AMPE患者CtnI明显升高,可作为判断病变预后的指标。Objective To find out the changes of cardiac troponin I （CtnI） in patients with acute massive pulmonary embolism （AMPE）.Methods A total of 58 patients with acute pulmonary thromboembolism （APTE）,diagnosed over the past 6 years in our hospital and underwent CtnI examination,were selected.Among them 19 patients with AMPE and 39 patients with non-AMPE,the CtnI concentration,blood gas analysis,right ventricular function,and prognosis of the patients between he two groups were compared.And the average value of serum CtnI at different time for AMPE patients was analyzed.Results There were significant differences between AMPE and non AMPE groups in CtnI value,blood gas analysis,right ventricular function and prognosis （P0.05）.The CtnI monitoring for AMPE group （15 patients） found that positive reaction（CtnI≥0.1μg/L）appeared in 5 hours and reached to the peak around 20 h.Conclusion The level of CtnI in patients with acute massive pulmonary embolism significantly increases,which could be used as a prognostic indicator of the disease.

关 键 词：急性大面积肺血栓栓塞症 心肌钙蛋白I 

分 类 号：R563.5[医药卫生—呼吸系统]