脑膜炎败血黄杆菌感染的危险因素及耐药性分析  

Infection of Chryseobacterium meningosepticum:Risk factor and antibiotic resistance

作　　者：张金锋[1] 

机构地区：[1]浙江省义乌市中心医院,浙江义乌322000

出　　处：《中国卫生检验杂志》2010年第9期2218-2219,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:了解义乌市中心医院脑膜炎败血黄杆菌感染的危险因素及耐药趋势,为临床治疗提供参考。方法:常规细菌培养方法采用法国生物梅里埃鉴定系统进行细菌鉴定。药敏试验采用K-B法。结果:从2006年1月-2009年12月四年间所送检的标本中共检出123株脑膜炎败血黄杆菌,最敏感的抗菌药物为哌拉西林/他唑巴坦,耐药率为5.2%。对其它抗菌药物的耐药率均超过80%。感染前1周内使用过抗菌药物112例(91.1%)各种侵袭性操作80例(65.0%)。结论:脑膜败血黄杆菌是一种高度耐药的细菌。临床治疗上应根据药敏结果选用抗菌药物。长期广谱抗菌药物的使用及多种侵入性操作是导致感染的主要危险因素。Objective：To determine the risk factor and tendency of resistance of Chryseobacterium meningosepticum and to provide the reference for the clinical treatment.Methods： Routine bacteria culture.Bacteria identification adopted France BioMerieux identification system.The K-B method was applied for the drug susceptibility test.Results： A total of 123 strains of Chryseobacterium meningosepticum was isolated from Jan 2006 to Dec 2009.Chryseobacterium meningosepticum was resistant to multiple antibiotics.The most sensitive antibiotic to Chryseobacterium meningosepticum is piperacillin/ tazobactam（5.2%）.Other antibiotic-resistant rates were higher than（80%）.Unsuitable application of antibiotics（91.1%） and various invasive treatments used（65.0%） were the main risk factors.Conclusion： Chryseobacterium meningosepticum showes high resistances to antibiotics.It is suggested that antibiotics should be used under the guidance of antibiotic susceptibility testing.Unsuitable application of antibiotics and various invasive treatments used were the main risk factors.

关 键 词：脑膜炎败血黄杆菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]