电感耦合等离子体原子发射光谱仪(ICP-AES)测定重组酵母乙肝疫苗中硫柳汞的含量  

Determination of Thimerosal Content in Recombinant Yeast Hepatitis B Vaccine by ICP-AES

作　　者：刘丽娟[1] 赵国雄[2] 邹健[2] 朱帆[1] 

机构地区：[1]武汉大学基础医学院,武汉430071 [2]中国药品生物制品检定所

出　　处：《中国药事》2010年第8期795-797,共3页Chinese Pharmaceutical Affairs

摘　　要：目的 ICP-AES测定重组酵母乙肝疫苗中硫柳汞的含量。方法样品消化后直接用ICP-AES检测。结果线性相关性好,重复性实验变异系数均小于4%,样品回收率超过99%。结论 ICP-AES能够满足重组酵母乙肝疫苗中硫柳汞含量检测的技术要求,是一种快速、有效、准确的分析方法。Objective To determine thimerosal content in recombinant yeast hepatitis B vaccine by Inductively Coupled Plasma Atomic Emission Spectrometer（ICP-AES）.Methods The samples were digested directly by ICP-AES detection.Results The linear correlation was good;repeatability coefficient of variation was less than 4%;the sample recovery rate was over 99%.Conclusion ICP-AES can meet the testing technical requirements to determine thimerosal content of recombinant yeast hepatitis B vaccine,which is a fast,effective and accurate analysis.

关 键 词：电感耦合等离子体原子发射光谱仪 重组酵母乙肝疫苗 硫柳汞含量 

分 类 号：R927.2[医药卫生—药学]