呋喃唑酮片溶出度试验方法的建立与研究  

Development and study of method for dissolution test of furazolidone tablets

作　　者：王昕[1] 唐素芳[1] 

机构地区：[1]天津市药品检验所,天津300070

出　　处：《药物分析杂志》2010年第8期1445-1447,共3页Chinese Journal of Pharmaceutical Analysis

基　　金：中国药典2010年版药典科研课题

摘　　要：目的:建立呋喃唑酮片的溶出度测定方法。方法:采用桨法,以1.8%的十二烷基硫酸钠为溶出介质,转速100r.min-1,溶出60min,采用紫外分光光度法,在367nm的波长处进行测定。结果:呋喃唑酮在2～12μg·mL-1浓度范围内线性关系良好,A=7.57×10-2C+2.1×10-3,r=0.9999(n=6);平均回收率(n=12)为99.7%;样品溶出度均一性良好。结论:本法快速简便,可作为呋喃唑酮片的质量控制方法。Objective：To establish the method of dissolution test of furazolidone tablets.Methods：The paddle method was used with 1.8% sodium laurylsulfate as dissolution medium at a rotate speed of 100 r·min-1,dissolution time was 60 minutes.Then it is determined by UV spectrophotometic method with detection wavelength of 367 nm.Results：The linear range of furazolidone was 2-12 μg·mL-1,A=7.57×10-2C＋2.1×10-3,r=0.9999（n=6）;The average recovery （n=12） was 99.7%.Conclusion：This method is rapid and convenient.It can be applied to determine dissolution of furazolidone tablets.

关 键 词：呋喃唑酮片 溶出度 紫外分光光度法 

分 类 号：R917[医药卫生—药物分析学]