高原健康人与高原红细胞增多症患者血浆EPO含量分析  

THE PLASMA ERYTHROPOIETIN ANALYSIS IN HIGH ALTITUDE NORMAL CONTROL AND HIGH ALTITUDE POLYCYTHEMIA

作　　者：裴澍萱[1] 次仁布芷[1] 沙珍[1] 郑俊[1] 黄益民[2] 刘舒[2] 刘艳霞[2] 张世馥[3] 牟信兵[4] 

机构地区：[1]西藏自治区第二人民医院 [2]北京市心肺血管疾病研究所 [3]中国医学科学院基础医学研究所 [4]西藏军区总医院

出　　处：《西藏医药》1999年第2期1-3,共3页Tibetan Medicine

基　　金：国家自然科学基金

摘　　要：目的：通过高原人血浆EPO测定，探索高原红细胞增多症（HAPC）的发病机理。方法：采用酶标法规定111例血浆EPO。结果：藏族健康者36例，EPO均值为6．13mlU／ml；汉族健康者36例，均值为10．69mlU／ml；藏族HAPC20例，均值为13．06mlU／ml；汉族HAOC19例均值为61．24mlU／ml。结果提示：汉族无论健康组还是HAPC病人组都高于藏族；且HAPC病人EPO含量高于健康者。结论：在高原低氧环境下，EPO增加可使RBC增多，从而引起HAPC，但这不是唯一的因素，有关调控机制正在进行深入研究。We report the estimation of plasma erythropoietin (EPO) in four groups: high altitude normal control - high altitude native (Tibetan nationality) and low - level immigrant (Han nationality) ; high altitude polycythemia patients of both nationalities.The HAPC patients have statistically significant high EPO concentration than normal control, and the Han - group has higher EPO value in both control and HAPC groups. Blood hemoglobin and hematocrit have dose-response relationship with EPO value. However the relationship value is rather low. The result indicates that in high altitude, some people have excessive erythrocytosis because of high level EPO,and eventually develop HAPC. But HAPC can not be distinguished from normal control just by the basis of EPO value.

关 键 词：促红细胞生成素 红细胞增多症 HAPC 

分 类 号：R555.1[医药卫生—血液循环系统疾病]