皮质骨骨痂延长骨愈合的组织形态学观察  

A Histomorphological Investigation on Callus Distraction of Cortical Bone

作　　者：黄劲松[1] 侯筱魁[1] 朱振 安盛为 

机构地区：[1]上海第二医科大学附属第九人民医院骨科

出　　处：《中国矫形外科杂志》1999年第3期197-199,共3页Orthopedic Journal of China

摘　　要：对皮质骨骨痂延长骨愈合过程的组织形态学变化进行观察。方法：在山羊左胫骨中段骨膜下横形截骨后用Ｉｌｉｚａｒｏｖ式外固定器固定。２周后作牵拉延长，每天１ｍｍ，连续３０天。定期摄Ｘ线片，并于截骨后１、２周，延长开始后１、２周，延长结束及结束后２、４、８、１２、１６周分期取材，作普通及偏光观察。结果：在骨痂延长早期，骨外膜侧即有直接骨形成，而延长间隙中先形成纤维组织，以后逐渐向纤维骨痂、骨性骨痂演变，最终形成新生皮质骨。结论：皮质骨骨干截骨后持续缓慢牵拉，对形成中的骨痂施以轴向的机械性张应力，能维持并刺激骨与软组织的再生，使截骨端间获得完全的骨愈合。其成骨方式可能以膜内骨化为主。Objective:To observe the histomorphological change of callus distraction of cortical bone.Method:The left sheep tibia was fixed by Ilizarov external fixator.Subperiosteal transverse osteotomy was performed at the diaphyseal site.Successive distraction persisted for 30 days at the rate of 1mm/day after 2 weeks delay,and radiography was taken periodically.After sacrifice,the samples of the elongation segment were observed by light and polar microscope.Results:Direct osteogenesis occurred at the periosteal side in the early stage of distraction,whilst in the distraction gap,the fibrous tissue formed firstly and transformed to fibrous callus and bony callus gradually,resulting in the formation of new cortical bone ultimately.Conclusion:Successive and slow distraction after osteotomy can subject the forming callus to the axial tensile stress,which maintain and stimulate the growth of new bone and soft tissue,leading to the complete healing of osteotomized bone ends.Intramembranous may be the chief ossification mode.

关 键 词：骨痂延长 组织形态学 实验 外科手术 

分 类 号：R687.3[医药卫生—骨科学]