非洛地平缓释片与尼群地平片治疗高血压病的疗效比较  

Felodipine extended_release tablet vs nitrendipine tablet in treating hypertension

作　　者：姜振泼 吴永群[1,2] 田德太 房锡晓 周祖浩 

机构地区：[1]即墨市第三人民医院 [2]即墨市人民医院

出　　处：《中国新药与临床杂志》1999年第2期73-74,共2页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的：比较非洛地平缓释片与尼群地平片治疗高血压病的疗效。方法：轻、中度高血压病病人１６２例，其中９８例（男性６７例，女性３１例，年龄５１ａ±ｓ６ａ）用非洛地平缓释片５～１０ｍｇ，ｐｏ，ｑｄ×４ｗｋ治疗。另６４例（男性４７例，女性１７例，年龄５０ａ±８ａ）用尼群地平片１０ｍｇ，ｐｏ，ｂｉｄ或ｔｉｄ×４ｗｋ治疗。结果：非洛地平缓释片组总有效率９５％，与尼群地平片组（８１％）相比，差别有非常显著意义（Ｐ＜０．０１）。不良反应发生率非洛地平缓释片组１５％，与尼群地平片组（２０％）比较，差别有显著意义（Ｐ＜０．０５）。结论：非洛地平缓释片对高血压病的疗效显著而又安全，优于尼群地平片。AIM: To compare the effects of felodipine extended_release(ER) with nitrendipine on hypertensive disease. METHODS: Among 162 mild to moderate hypertensive patients, 98 patients (M 67, F 31, age 51 a±s 6 a) received felodipine_ER 5_10 mg, po, qd for 4 wk; 64 patients (M 47, F 17, age 50 a±8 a) received nitrendipine 10 mg, po, bid or tid for 4 wk. RESULTS: The clinical total effective rate of felodipine_ER group was higher than that of nitrendipine group (95% vs 81%, P<0.01). Adverse effects of felodipine_ER group were fewer than those of nitrendipine group (15% vs 20%, P<0.05). CONCLUSION: Felodipine_ER is a safe and effective drug on hypertensive disease, and superior to nitrendipine. 1The People's Hospital of Jimo City, Jimo SHANDONG 266200

关 键 词：非洛地平 尼群地平 高血压 治疗 

分 类 号：R544.1[医药卫生—心血管疾病]