IgA肾病不同年龄组临床与病理特点分析  

Clinical and pathological analysis of 250 IgA nephropathy patients in different age groups

作　　者：伍巧源[1] 李洁[1] 黄莉[1] 杨桢华[1] 霍冬梅[1] 廖蕴华[1] 

机构地区：[1]广西医科大学第一附属医院肾内科,南宁市530021

出　　处：《实用医学杂志》2010年第18期3374-3376,共3页The Journal of Practical Medicine

基　　金：广西科技厅基金(编号:桂科基0156022)

摘　　要：目的:回顾性分析不同年龄组IgA肾病患者的临床与病理特点。方法:回顾性分析250例IgA肾病患者的临床与肾活检病理资料。以每10岁为一年龄组,对IgA肾病患者的临床分型、病理分级、组织病理学改变按年龄分组后进行分析。结果:250例患者临床分型中,11～50岁4个年龄组均以尿检异常型(U-ab)最常见,51～60岁年龄组以高血压型(HT)所占的比例为最高(29.4%),在≥61岁年龄组则以大量蛋白尿型(MP)所占的比例为最高(42.9%)。病理资料收集完整的为249例。11～30岁这两个年龄组均以Ⅲ级病理改变最常见;30岁以后各年龄组则以Ⅳ级病理改变最常见。球性硬化、肾小管萎缩、间质纤维化积分总体上存在随年龄增加而升高的趋势。结论:IgA肾病具有随年龄增大,其临床及病理改变渐趋严重的趋势。Objective To investigate the clinical and pathological characteristics of IgA nephropathy （IgA N） in different age groups. Methods 250 patients with primary IgA N were enrolled and divided into 6 groups according to their age. The clinical and pathological characteristics of IgA N in different age groups were analyzed retrospectively. Results While the most common clinical symptom in 11 to 50 years old group was asymptomatic abnormal urinalysis （U-ab）, the clinical symptom in the 51 to 60 years old group was mainly hypertension. And in the group older than 61, mass proteinuria subtype was observed most commonly. In group age from 11 to 30 years old, the level of pathological lesions was mainly Grade Ⅲ. And it was mainly Grade Ⅳ for groups older than 31 years old. In general, a tendency that the scores of global glomerulosclerosis, tubular atrophy and interstitial fibrosis increased with age was observed.Conclusion Clinical presentations and pathological lesions of IgA N become more severe with increasing age.

关 键 词：IGA肾病 临床分型 肾脏病理 

分 类 号：R692.3[医药卫生—泌尿科学]