肿瘤患者深部真菌感染的菌株分布及耐药性分析  

Microbial Flora Distribution and Drug-Resistance in Tumor Patients with Deep Fungal Nosocomial Infection

作　　者：李桂秋[1] 刘文博[1] 宋熙瑶[1] 罗文涛[1] 崔兰英[1] 路娟[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院微生物科,黑龙江哈尔滨150001

出　　处：《微生物学杂志》2010年第4期36-38,共3页Journal of Microbiology

基　　金：中国博士后基金(20090919);哈尔滨医科大学第一临床医学院基金(2009B18)

摘　　要：探讨肿瘤患者深部真菌医院感染的病原菌分布特点及耐药现状。回顾性分析2008年1月至2009年12月哈尔滨医科大学第一临床医学院住院肿瘤患者送检标本分离出的173株真菌的分布及耐药情况。肿瘤患者深部真菌医院感染以下呼吸道感染为主，占76．3％，真菌种类主要是白假丝酵母菌（74．6％）；真菌药敏试验结果表明，深部真菌对两性霉素B和5-氟胞嘧啶耐药率均〈5％；对伊曲康唑及伏立康唑的耐药率为0—6．5％；对氟康唑耐药率有上升趋势，为2．5％-25．0％。临床分离的真菌主要集中在呼吸道标本，以白假丝酵母菌为主，对抗真菌药物普遍敏感，应积极治疗，合理利用抗真菌药物，改善患者预后，减少耐药菌株的产生。In order to approach the microbial flora distribution and drug-resistance status in deep fungal nosocomial infection in tumor patient＇s retrospective reviews were performed to analyze the 173 cases of deep fungal nosoeomial infections in tumor department. The resuhs showed that the lower respiratory tract was the main site in deep fungal nosocomial infection in tumor patients, accounting for 76.3 %. The digestive tract infection rated the second, accounting for 13.1%. The main species of fungi were Candida albicans （74.6%）. The susceptibility test showed that the drug-resistance rate to amphotericin B and 5-fluorocytosine were less than 5% , and that to itraeonazole and voriconazole was 0 ~ 7.6%. The resistance rate （ 17. 1% ~ 30.0% ） to fluconazole showed upgrading tendency. Therefore, the main fungal species of isolated from clinic were C. albicans which was susceptible to antifungal agents. It is important to give active treatment and choose antifungal agents reasonably to improve the prognosis and reduce drug-resistant strains. And to think highly of aetiological detection and monitoring of drug-resistance in deep fungal nosocomial infections in tumor patients in order to control the infections effectively.

关 键 词：肿瘤患者 医院感染 深部真菌 抗真菌药物 

分 类 号：R379[医药卫生—病原生物学]