2型糖尿病合并肺结核患者T淋巴细胞亚群变化研究  

Study on Changes of T Homeocyte Subgroup of Patients with Pulmonary Tuberculosis and Type 2 Diabetes

作　　者：赵辉[1] 邢应如 张荣波[1] 

机构地区：[1]安徽理工大学医学院,淮南232001 [2]安徽东方医院集团肿瘤医院检验科

出　　处：《医学动物防制》2010年第8期701-702,共2页Journal of Medical Pest Control

摘　　要：目的探讨2型糖尿病合并肺结核患者外周血T淋巴细胞亚群的变化。方法利用流式细胞术对36例2型糖尿病合并肺结核患者(III组)、41例2型糖尿病患者(II组)、43例肺结核患者(I组)、30例健康者(健康对照组)检测外周血T淋巴细胞亚群CD3+、CD4+、CD8+的变化,对测定结果进行统计学分析。结果 III组外周血CD3+明显低于I组、II组、健康对照组(P均<0.05),CD4+明显低于健康对照组(P<0.05),CD4+/CD8+明显低于II组、健康对照组(P均<0.05),CD8+显著高于II组、健康对照组(P均<0.05),而CD4+、CD8+、CD4+/CD8+与I组比较差异无统计学意义(P>0.05);II组CD3+、CD4+、CD4+/CD8+显著低于健康对照组(P<0.05),CD8+与健康对照组比较无统计学意义(P>0.05);I组CD3+、CD4+、CD4+/CD8+低于健康对照组(P<0.05),CD8+明显高于健康对照组(P<0.05)。结论 2型糖尿病合并肺结核患者存在T淋巴细胞亚群的变化,存在着细胞免疫功能缺陷。Objective To explore the change and clinical significance of CD3^＋,CD4^＋,CD8^＋ type 2 diabetes mellitus with lung tuberculosis patients.Method Determine the CD3^＋,CD4^＋ and CD8^＋ values in 36 type 2 diabetes mellitus with lung tuberculosis patients,41 type 2 diabetes mellitus patients,43 lung tuberculosis patients and 30 normal persons with Flow Cytometry.And then make a statistical analysis based on the determining results.Results The activities of CD3^＋ in the 2 diabetes mellitus patients with lung tuberculosis were significantly lower than type 2 diabetes mellitus patients,lung tuberculosis and healthy persons（P〈0.05）,CD4^＋ were significantly lower than healthy persons group （P〈0.05）,CD4^＋/CD8^＋ significantly lower than type 2 diabetes mellitus patients and healthy persons（P〈0.05）,while CD8^＋ were significantly higher than type 2 diabetes mellitus patients and healthy persons（P〈0.05）.There was no statistical difference between CD4^＋,CD8^＋.The type 2 diabetes mellitus patients with lung tuberculosis and lung tuberculosis.The level of the type 2 diabetes mellitus with CD3^＋,CD4^＋,CD4^＋/CD8^＋ were significantly lower than healthy persons （P〈0.05）.There is no statistical difference with CD8^＋ between the type 2 diabetes mellitus patients with lung tuberculosis and healthy persons.The level of lung tuberculosis with CD3^＋,CD4^＋,CD4^＋/CD8^＋ were significantly lower than healthy persons（P〈0.05）.CD8^＋ were higher than healthy people（P〈0.05）.Conclusions T lymphocytes subsets were changed and cellular immunity was deficient in type 2 diabetes mellitus patients with lung tuberculosis.

关 键 词：糖尿病 肺结核 T淋巴细胞亚群 

分 类 号：R587.1[医药卫生—内分泌] R521[医药卫生—内科学]