甲硝唑降血脂临床观察及唾液药物浓度监测  

CLINICAL OBSERVATION OF MN IN TREATMENT OF HYPERLIPEMIA AND ITS SALIVA DRUG CONCENTRATION MONITORING

作　　者：爱民[1,2,3] 贾海鹰[1,2,3] 肖跃平[1,2,3] 李展逵 焦效兰[1,2,3] 杨毓章[1,2,3] 杨铮[1,2,3] 陈淑敏[1,2,3] 

机构地区：[1]内蒙古医学院药理学教研室 [2]内蒙古医学院第一附属医院 [3]内蒙古电建二公司卫生所

出　　处：《内蒙古医学院学报》1999年第1期25-27,共3页Acta Academiae Medicinae Neimongol

基　　金：内蒙古自然科学基金

摘　　要：目的：评价甲硝唑降血脂疗效及唾液甲硝唑浓度监测。方法：２３例高血脂症采用口服甲硝唑三种给药方案治疗：Ⅰ．０６ｇｔｉｄ×１０ｄ，ｎ＝６。Ⅱ．０４ｇｔｉｄ×１０ｄ，ｎ＝１０。Ⅲ．０２ｇｔｉｄ×１０ｄ，ｎ＝７。结果：三种方案甘油三酯下降总有效率为６６７％，６００％及４２８％；胆固醇下降总有效率为６６７％，６００％及４２８％。三种方案治疗后血脂下降百分数为：甘油三酯为６２３％，３４６％及３１０％；胆固醇为３０４％，１７５％及１９４％。唾液中甲硝唑Ｃｓ三种方案依次为３１３９，２０６０及１６２０μｇ／ｍｌ。结论：甲硝唑降甘油三酯和胆固醇作用快速、明显。甲硝唑唾液浓度监测ＣＳＳ有剂量依赖性，符合药物动力学规律。Objective: To evaluation of MN in treatment of hypenlipemia and its saliva drug concentration monitoring. Methods:23 hyperlipemia patients were treated by Metronidazole (MN)orally. Three MN dosage schemes were administrated:(Ⅰ)0 6g tid ×10d,n=6;(Ⅱ)0 4g tid ×10d,n=10;(Ⅲ)0 2g tid×10d,n=7.Results:After 10 days MN therapy, the total curative rates of three schemes for triglyceride were 66.7%,60.0% and 42.8%, for cholesterol were 66.7%,60.0% and 42.8%. The decrease % of serum lipids of three schemes for triglyceride were 62.3%,34.6% and 31.0%, for cholesterol 30.4%,17.5% and 19.4%. The MN saliva C ss of three schemes were 31.39, 20.60 and 16.20 μg/ml.Conclusion: The function of MN bringing down triglyceride and cholesterol is quick and obvious. MN has the dependence on the dosage in determining C ss in salivary concentration.

关 键 词：甲硝唑 血症过多 甘油三酯 胆固醇 唾液浓度 

分 类 号：R972.6[医药卫生—药品] R978.61[医药卫生—药学]