再探奥昔非君保护缺血心肌的作用及机理  

EFFECTS OF OXYFEDRINE ON MYOCARDIAL NECROSIS IN RATS

作　　者：于洁[1] 谢军[1] 李希贤[1] 

机构地区：[1]内蒙古医学院药理学教研室

出　　处：《内蒙古医学院学报》1999年第1期31-32,共2页Acta Academiae Medicinae Neimongol

摘　　要：目的：再探奥昔非君对缺血心肌的保护作用及其机理。方法：建立小鼠垂体后叶素性心肌缺血模型，从自由基角度，观察用药前后缺血心肌血液供应及自由基损伤反应。结果：奥昔非君（Ｏｘｙ）能显著提高缺血心肌的营养血供应；降低心肌氧自由基（ＯＦＲ）浓度和丙二醛（ＭＤＡ）含量；增加超氧化物歧化酶（ＳＯＤ）活性。结论：Ｏｘｙ具有显著保护缺血心肌损伤的作用，可改善缺血心肌的血液灌流，增加机体抗氧化能力，减轻自由基损伤反应的结果。Objective:To explore the effects and mechanism of oxyfedrine (Oxy) on myocardial necrosis in rats.Methods:To establish pituitrinal myocardial necrosis model on rats mimicked and investigated the myocardial nutritional blood flow(NBF),oxygen free radical(OFR),malondialdehyde(MDA) content and superoxide dismutase(SOD) activity.Results:The experimental study showed Oxy significant increase NBF,SOD activity and decrease OFR,MDA content in model rats.Conclusion:The protective effects on myocardial necrosis might be relate to the increased myocardial nutritional blood flow and the decreased abnormal free radical reactions by Oxy.

关 键 词：奥昔麻黄碱 冠状动脉疾病 自由基 药理 

分 类 号：R972[医药卫生—药品] R965.2[医药卫生—药学]